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首页> 外文期刊>麻酔 >A case of successful thrombolysis by recombinant tissue plasminogen activator for postoperative pulmonary thromboembolism
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A case of successful thrombolysis by recombinant tissue plasminogen activator for postoperative pulmonary thromboembolism

机译：重组组织纤溶酶原激活剂成功溶栓治疗术后肺血栓栓塞的病例

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A 52-year-old female suspected of hypercoagulability underwent modified radical hysterectomy and left oophorectomy for uterus cancer and left giant ovarian tumor under general combined with epidural anesthesia. On the day after the operation, the patient complained of dyspnea and developed tachypnea, a low Spo2, and hypotension after the intermittent external pneumatic compression of the legs. Echocardiography showed acute right cardiac failure and pulmonary angiography revealed massive pulmonary thromboembolism. The patient fell into shock with severe hypotension and unconsciousness during the catheter fragmentation and aspiration therapy for pulmonary thrombi. Bolus intravenous injection of monteplase 1.6 million units, a mutant of tissue plasminogen activator with a longer half-life, rapidly improved the shock status and stabilized the hemodynamic condition. Monteplase would be useful for life-threatening pulmonary thromboembolism although the risk of hemorrhagic complication remains.
机译：一位52岁的女性涉嫌高凝血管性，接受了改性的根治性子宫切除术，对子宫癌和左巨型卵巢肿瘤的遗传术与硬膜外麻醉。在手术后一天，患者抱怨呼吸困难，并在腿部间歇性外部气动压缩后开发了Tachypnea，低SPO2和低血压。超声心动图显示急性右心衰竭，肺血管造影显示出大量的肺血栓栓塞。患者在导管碎片和肺血栓检查中的严重低血压和无意识中遭受冲击。推注静脉注射蒙特普酶160万单位，一种组织纤溶酶原激活剂的突变体，半衰期较长，迅速提高了休克状态并稳定血流动力学条件。蒙特普酶对于危及生命的肺血栓栓塞，尽管仍然存在出血并发症的风险。

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