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The heart rate variability in mice: telemetric evaluation of endotoxin shock

机译：小鼠心率变异：内毒素休克的遥测评估

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BACKGROUND: Recently, the knowledge regarding all types of shock has increased. In the critical period, the maintenance of perfusion to important organs and of autonomic cardiovascular control is a clue to improve outcome. The current investigation studied the effects of endotoxin shock on the heart rate variability (HRV), which might be an early marker of multiple organ dysfunction syntion. METHODS: CL 57 BL/6 J mice (30-32 g) were implanted with intra-abdominal telemetry transmitters and data collection began 7 days after surgery and continued for 5 hours after the treatment. In endotoxin group, 3 mg x kg(-1) of E. coli lipopylysaccharide (0127 : B 8) was administered intraperitoneally and the same dose of saline was administered in control group. From the beat-by-beat values, heart rate (HR), standard deviation and coefficients of variation (RMSSD) were calculated. Integrated values of power spectral density were derived by summing depending on the frequency ranges, which were chosen with respect to the results of the previous investigation as follows: very low frequency (VLF) < 0.15 Hz; low frequency (LF), 0.15-1.5 Hz; and high frequency (HF), 1.5-5.0 Hz. RESULTS: HR showed no difference between the groups. RMSSD, Total Power, VLF, LF and HF increased in control group throughout the experiments, but, decreased in endotoxin group even 5 hr after the treatment. CONCLUSIONS: There has been scarce information on mice HRV, but we have demonstrated that endotoxin administration significantly decreases RMSSD and spectral density at low and high frequencies.
机译：背景：最近，关于所有类型的冲击的知识都增加了。在关键期间，对重要器官和自主心血管控制的维持灌注是一种改善结果的线索。目前的调查研究了内毒素冲击对心率变异性（HRV）的影响，这可能是多器官功能障碍术的早期标记。方法：将Cl 57 Bl / 6 J小鼠（30-32g）植入腹部遥测发射器和数据收集在手术后7天开始，并在治疗后持续5小时。在内毒素基团中，腹膜内施用3mg X kg（-1）大肠杆菌脂肪酸（0127：B 8），并在对照组中施用相同剂量的盐水。从逐拍值，计算心率（HR），标准偏差和变化系数（RMSD）。通过根据频率范围的求和来导出功率谱密度的集成值，该频率范围是相对于先前调查结果选择的频率范围，如下所示：非常低频（VLF）<0.15Hz;低频（LF），0.15-1.5 Hz;和高频（HF），1.5-5.0 Hz。结果：人力资源在群体之间没有显示出区别。在整个实验中，对照组的RMSSD，总功率，VLF，LF和HF增加，但在治疗后，内毒素组甚至5小时降低。结论：对小鼠HRV有稀缺的信息，但我们已经证明了内毒素给药在低频率下显着降低了RMSD和光谱密度。

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