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首页> 外文期刊>麻酔 >Neuromuscular blocking effects, pharmacokinetics and safety of Org 9426 (rocuronium bromide) in Japanese patients
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Neuromuscular blocking effects, pharmacokinetics and safety of Org 9426 (rocuronium bromide) in Japanese patients

机译：日本患者中的神经肌肉阻断效应，药代动力学和org 9426（罗孔溴化物）的安全性

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BACKGROUND: The purpose of this study was to examine pharmacodynamics, pharmacokinetics and safety of Org 9426 (rocuronium bromide) in Japanese patients. METHODS: Seventy-eight patients anesthetized with thiopental, droperidol, fentanyl and nitrous oxide, were randomized to receive either a single dose of Org 9426 0.3 mg x kg(-1), 0.6 mg x kg(-1) or 0.9 mg x kg(-1). Contraction of the adductor pollicis to the ulnar nerve stimulation (0.1 Hz) was measured by acceleromyography. Blood was sampled over 6 hr and pharmacokinetic variables were calculated by plasma concentrations of Org 9426. RESULTS: Onset times for patients receiving 0.3 mg x kg(-1), 0.6 mg x kg(-1) or 0.9 mg x kg(-1) were 271.5 s, 140.0s and 125.4s, respectively. There was a dose-dependent increase in clinical durations until 25% recovery of twitch height (17.4 min in 0.3 mg x kg(-1) group, 37.2 min in 0.6 mg x kg(-1) and 60.4 min in 0.9 mg x kg(-1) group). Pharmacokinetic study revealed that elimination half life, steady state volume of distribution and plasma clearance of Org 9426 were 48-76 min, 146-181 ml x kg(-1), and 3.8-4.5 ml x min(-1) x kg(-1), respectively. No adverse effects were found except a case of local erythema on a forearm. CONCLUSIONS: The efficacy of neuromuscular block, stable pharmacokinetic behavior and excellent safety of Org 9426 were also confirmed in Japanese surgical patients.
机译：背景：本研究的目的是在日本患者中检查药效学，药代动力学和org 9426（罗孔溴化物）的药代动力学和安全性。方法：随机用硫喷妥，戊醇，芬太尼和氧化亚烷基含有七十八名患者，接受单剂量的org 9426 0.3mg x kg（-1），0.6mg x kg（-1）或0.9mg x kg （-1）。通过加速度测量，测量收缩剂对尺神经刺激（0.1Hz）的收缩。在6小时内取样血液，并通过血浆9426血浆浓度计算药代动力学变量。结果：患者发病时间为0.3mg x kg（-1），0.6mg x kg（-1）或0.9mg x kg（-1 ）分别为271.5秒，140.0秒和125.4s。临床持续时间有剂量依赖性增加，直到抽搐高度的25％（0.3mg x kg（-1）组17.4分钟，37.2分钟，在0.9mg x kg中为0.6mg x kg（-1）和60.4分钟（-1）组）。药代动力学研究表明，消除半衰期，锻造半衰期，稳态的分布和血浆间隙的org 9426为48-76分钟，146-181ml x kg（-1）和3.8-4.5ml x min（-1）x kg（ -1）分别。除了前臂上的局部红斑外，没有发现不利影响。结论：在日本手术患者中还确认了神经肌肉嵌段，稳定的药代动力学行为和优异的org 9426的优异安全性。

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