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首页> 外文期刊>麻酔 >Effects of sevoflurane and propofol on neuromuscular blocking action of Org 9426 (rocuronium bromide) infused continuously in Japanese patients
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Effects of sevoflurane and propofol on neuromuscular blocking action of Org 9426 (rocuronium bromide) infused continuously in Japanese patients

机译：七氟醚和异丙酚对日本患者连续注入的org 9426（罗孔溴化物）神经肌肉阻断作用的影响

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摘要

BACKGROUND: The purpose of this study was to investigate the interaction of anesthetic agents with Org 9426 (rocuronium bromide) infused continuously. The effect of intubation dose of Org 9426 on its infusion rate was also investigated. METHODS: Total of 38 Japanese patients were randomly allocated either to receive intubation dose of 0.6 or 0.9 mg x kg(-1) of Org 9426. These patient groups were anesthetized with either sevoflurane or propofol. Infusion of Org 9426 was started with the initial infusion rate of 7 microg x kg(-1) x min(-1) when T1 reappeared after the intubation dose. The infusion rate was adjusted to keep the height of T1 between 3-10% of the control value. RESULTS: The rates of infusion 90 min after the start of infusion were 3.4, 7.5, 3.9 and 7.7 microg x kg(-1) x min(-1) for the 0.6 mg x kg(-1)-sevoflurane, 0.6 mg x kg(-1) propofol, 0.9 mg x kg(-1)-sevoflurane and 0.9 mg x kg(-1) propofol groups, respectively. Sevoflurane significantly reduced the infusion rate with both intubation doses. The mean infusion rates of 0.9 mg x kg(-1) groups were slower than those of 0.6 mg x kg(-1) groups up to 60 min after the start of infusion. Mean clearance of Org 9426 during infusion was not different between sevoflurane and propofol anesthesia. CONCLUSIONS: Patients receiving sevoflurane anesthesia required a markedly lower Org9426 infusion rate compared with patients receiving propofol anesthesia.
机译：背景：本研究的目的是研究麻醉剂与连续注入的麻醉剂与org 9426（罗孔溴化物）的相互作用。还研究了插管剂量的org 9426对其输注速率的影响。方法：总共38例日本患者随机分配，以接受0.6或0.9mg x Kg（-1）org 9426的插管剂量。这些患者基团与七氟醚或异丙酚麻醉。当T1在插管剂量后重新出现时，术后锻炼org 9426的输注术初始输注速率为7 microg x kg（-1）x min（-1）。调整输液速率以使T1的高度保持在控制值的3-10％之间。结果：输注开始后90分钟的输液率为3.4,7.5,3.9和7.7 microg x kg（-1）x min（-1），用于0.6mg x kg（-1）-sevoflulane，0.6mg x kg（-1）丙啉，0.9mg x kg（-1）-sevoflulane和0.9mg x kg（-1）丙啉基团。七氟醚显着降低了两种插管剂量的输注速率。 0.9mg X kg（-1）组的平均输注速率比输注开始后60分钟的0.6mg x kg（-1）组较慢。在输注过程中的org 9426的平均间隙在七氟醚和异丙酚麻醉之间不含量。结论：患者接受七氟醚麻醉与接收异丙酚的患者相比，需要显着较低的Org9426输注速率。

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  • 来源
    《麻酔》 |2006年第8期|共8页
  • 作者

    Takagi S; Ozaki M; Iwasaki H; Hatano Y; Takeda J;

  • 作者单位

    Department of Anesthesiology Tokyo Women's Medical University School of Medicine Tokyo 162-8666.;

    Dipartimento di Chimica Ingegneria Chimica e Materiali Universita di L'Aquila 67010 Coppito Due L'Aquila Italy Dipartimento di Chimica Universita di Roma "La Sapienza" P.le A.Moro 5 00185 Roma Italy and Istituto di Strutturistica Chimica "Giordano Giacome;

    Dipartimento di Chimica Ingegneria Chimica e Materiali Universita di L'Aquila 67010 Coppito Due L'Aquila Italy Dipartimento di Chimica Universita di Roma "La Sapienza" P.le A.Moro 5 00185 Roma Italy and Istituto di Strutturistica Chimica "Giordano Giacome;

    Dipartimento di Chimica Ingegneria Chimica e Materiali Universita di L'Aquila 67010 Coppito Due L'Aquila Italy Dipartimento di Chimica Universita di Roma "La Sapienza" P.le A.Moro 5 00185 Roma Italy and Istituto di Strutturistica Chimica "Giordano Giacome;

    Dipartimento di Chimica Ingegneria Chimica e Materiali Universita di L'Aquila 67010 Coppito Due L'Aquila Italy Dipartimento di Chimica Universita di Roma "La Sapienza" P.le A.Moro 5 00185 Roma Italy and Istituto di Strutturistica Chimica "Giordano Giacome;

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  • 正文语种 jpn
  • 中图分类 外科手术学;
  • 关键词

    Infusion; NOS; sevoflurane; Propofol; Minute of time; 二异丙酚;

    机译：Infusion;NOS;sevoflurane;Propofol;Minute of time;二异丙酚;

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