...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Academic radiology >MR spectroscopy using normalized and non-normalized metabolite ratios for differentiating recurrent brain tumor from radiation injury.
【24h】

MR spectroscopy using normalized and non-normalized metabolite ratios for differentiating recurrent brain tumor from radiation injury.

机译：使用归一化和非归一化代谢物比率的MR光谱法可将复发性脑肿瘤与放射损伤区分开来。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

RATIONALE AND OBJECTIVES: To compare the ability of normalized versus non-normalized metabolite ratios to differentiate recurrent brain tumor from radiation injury using magnetic resonance spectroscopy (MRS) in previously treated patients. MATERIALS AND METHODS: Twenty-five patients with previous diagnosis of primary intracranial neoplasm confirmed with biopsy/resection, previously treated with radiation therapy (range, 54-70 Gy) with or without chemotherapy and new contrast enhancing lesion on a 1.5 T magnetic resonance imaging at the site of the primary neoplasm participated in this retrospective study. After MRS, clinical, radiological, and histopathology data were used to classify new contrast-enhancing lesions as either recurrent neoplasm or radiation injury. Volume of interest included both the lesion and normal-appearing brain on the contralateral side. Non-normalized metabolic ratios were calculated from choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) spectroscopic values obtained within the contrast-enhancing lesion: Cho/Cr, NAA/Cr, and Cho/NAA. Normalized ratios were calculated using the metabolic values from the contralateral normal side: Choormal creatinine (nCr), Choormal N-acetylaspartate (nNAA), Choormal choline, NAANAA, NAACr, and CrCr. Results were correlated with the final diagnosis by Wilcoxon rank-sum analysis. RESULTS: Two of three non-normalized ratios, Cho/NAA (sensitivity 86%, specificity 90%) and NAA/Cr (sensitivity 93%, specificity 70%) significantly associated with tumor recurrence even after correcting for multiple comparisons. Of the six normalized ratios, only ChoNAA significantly correlated with tumor recurrence (sensitivity 73%, specificity 40%), but did not remain significant after correcting for multiple comparisons. CONCLUSION: Cho/NAA and NAA/Cr were the two ratios with the best discriminating ability and both had better discriminating ability than their corresponding normalized ratios (Area under the curve = 0.92 versus 0.77, AUC= 0.85 vs. 0.66), respectively.
机译：理由和目的：为了比较归一化和非归一化代谢物比率在先前治疗过的患者中使用磁共振波谱（MRS）区分复发性脑肿瘤与放射损伤的能力。材料与方法：25名先前经活检/切除确诊为原发性颅内肿瘤的患者，经放射治疗（范围为54-70 Gy），并接受或不接受化疗，并在1.5 T磁共振成像上发现了新的对比增强病变在原发灶部位的患者参加了这项回顾性研究。 MRS后，将临床，放射学和组织病理学数据用于将新的对比增强病灶归类为复发性肿瘤或放射损伤。感兴趣的体积包括病变和对侧的外观正常的大脑。由胆碱（Cho），肌酸（Cr）和N-乙酰天门冬氨酸（NAA）光谱值在对比增强病变中获得的非标准化代谢率计算得出：Cho / Cr，NAA / Cr和Cho / NAA。使用对侧正常侧的代谢值计算归一化比率：Cho /正常肌酐（nCr），Cho /正常N-乙酰天冬氨酸（nNAA），Cho /正常胆碱，NAA / nNAA，NAA / nCr和Cr / nCr。结果与Wilcoxon秩和分析的最终诊断相关。结果：即使校正了多个比较，三个非标准化比率中的两个比率，Cho / NAA（敏感性86％，特异性90％）和NAA / Cr（敏感性93％，特异性70％）与肿瘤复发显着相关。在六个归一化比率中，只有Cho / nNAA与肿瘤复发显着相关（敏感性73％，特异性40％），但在校正多个比较后仍未保持显着性。结论：Cho / NAA和NAA / Cr是两个具有最佳辨别能力的比率，并且都具有比对应的归一化比率更好的辨别能力（曲线下的面积分别为0.92对0.77，AUC = 0.85对0.66）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号