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首页> 外文期刊>Academic radiology >Gray-scale contrast-enhanced ultrasonography for quantitative evaluation of the blood perfusion of the sciatic nerves with crush injury.
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Gray-scale contrast-enhanced ultrasonography for quantitative evaluation of the blood perfusion of the sciatic nerves with crush injury.

机译：灰度对比超声检查用于定量评估挤压伤坐骨神经的血液灌注。

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RATIONALE AND OBJECTIVES: Blood perfusion of peripheral nerves plays an important role in regeneration after nerve injury. Functional recovery after a peripheral nerve injury depends not only on the survival of the affected neurons but also on the recovered blood perfusion. Previous studies have shown that it is possible to quantitatively assess blood perfusion of tissue using contrast-enhanced ultrasound (CEUS). The aim of this study was to evaluate the usefulness of CEUS for the quantitative evaluation of blood perfusion of the sciatic nerves with crush injury. MATERIALS AND METHODS: Crush injuries were created in the left sciatic nerve of 30 New Zealand white rabbits. CEUS of the bilateral sciatic nerves was performed in six experimental rabbits at 3 days, 1 week, 2 weeks, 4 weeks, and 8 weeks after injury. Pulse-inversion harmonic imaging was used for real-time CEUS. The other six rabbits were used as a control group. Serial laser Doppler measurements of blood flow and quantitative histologic evaluation were performed parallel to CEUS on all animals. RESULTS: Quantitative analysis of CEUS showed that the perfusion index of the crushed sciatic nerves was increased at 3 days after injury, with a peak at 1 week after injury (P = .000). The area under the curve for the crushed sites was increased at 3 days after injury, with a peak at 2 weeks after injury (P = .000). The mean transit time and maximum intensity of the crushed site of the left sciatic nerves were not significantly changed during the 2 months after injury (P = .335 and P = .157 respectively). The perfusion indices measured by CEUS correlated well with those measured by laser Doppler (r = 0.791, P = .000). Marked Wallerian degeneration was found at the crushed site of sciatic nerves at 3 days after injury. The percentage of degenerated myelinated axons was increased during the first 2 weeks after injury and then decreased during the following period. Regenerated axons with small diameter and thin myelin sheaths were found at 2 weeks after injury and during the following period. CONCLUSIONS: CEUS may provide a new imaging method to quantitatively analyze blood perfusion of injured peripheral nerves.
机译：理由和目的：周围神经的血液灌注在神经损伤后的再生中起重要作用。周围神经损伤后的功能恢复不仅取决于受影响的神经元的存活，还取决于恢复的血液灌注。先前的研究表明，可以使用对比增强超声（CEUS）定量评估组织的血液灌注情况。这项研究的目的是评估CEUS在定量评估挤压伤性坐骨神经血液灌注方面的有用性。材料与方法：30只新西兰白兔的左坐骨神经受到挤压伤。在损伤后3天，1周，2周，4周和8周时，对六只实验兔进行双侧坐骨神经的CEUS。脉冲反转谐波成像用于实时CEUS。另外六只兔子用作对照组。在所有动物上，与CEUS平行进行了串行激光多普勒血流测量和定量组织学评估。结果：CEUS的定量分析表明，在受伤后3天，坐骨神经压迫指数增加，在受伤后1周达到峰值（P = .000）。压伤部位的曲线下面积在伤后3天增加，在伤后2周达到峰值（P = .000）。受伤后两个月内，左坐骨神经压迫部位的平均通过时间和最大强度没有明显变化（分别为P = .335和P = .157）。 CEUS测得的灌注指数与激光多普勒测得的灌注指数高度相关（r = 0.791，P = .000）。受伤3天后，在坐骨神经压迫部位发现明显的沃勒变性。变性髓鞘轴突的百分数在受伤后的前两周内增加，然后在随后的时期内降低。在受伤后2周和随后的一段时间内发现了直径较小且髓鞘薄的再生轴突。结论：CEUS可能提供一种新的影像学方法，以定量分析受伤的周围神经的血液灌注。

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