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首页> 外文期刊>Academic radiology >Diagnostic Performance of Contrast Enhanced Ultrasound in Patients with Prostate Cancer. A Meta-Analysis.
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Diagnostic Performance of Contrast Enhanced Ultrasound in Patients with Prostate Cancer. A Meta-Analysis.

机译：对比增强超声对前列腺癌患者的诊断性能。荟萃分析。

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Rationale and Objectives: We aimed to do a meta-analysis of the existing literature to assess the accuracy of prostate cancer (PCa) studies that use contrast-enhanced ultrasound (CEUS) as a diagnostic tool. Materials and Methods: The MEDLINE, EMBASE, and Cochrane Library databases were searched for relevant original articles published up to August 2012. Characteristics of Included studies were recorded. Methodological quality was assessed by using the quality assessment of diagnostic studies tool. Pooled weighted estimates of diagnostic odds ratio (DOR), sensitivity, specificity, and positive and negative likelihood ratio (LR) were calculated. A summary receiver operator characteristic (SROC) curve was constructed to calculate the area under the curve (AUC). Publication bias analysis was also performed. Results: Sixteen studies (2624 patients) were included in the meta-analysis. Various contrast agents and imaging modes were applied. The independent random-effects summary showed a variation in diagnostic values. The summary estimates of sensitivity, specificity, and DOR were 0.70, 0.74, and 9.09, respectively. The weighted positive and negative LR were 2.81 and 0.35, with statistically significant between-study heterogeneity (P < .001). Sensitivity was better in positive patient studies than positive biopsy cores ones (0.78 vs. 0.64). SROC plot displayed value for AUC (0.82). Begg's test (P = .822) and Egger's test (P = .198) did not show evidence of publication bias. Conclusion: CEUS is a promising tool in the detection of PCa, but it cannot completely replace systematic biopsy under the present circumstances. It is necessary to standardize imaging techniques, contrast agents and diagnostic criteria. Large samples, multi-center studies and high-quality prospective trials are necessary to assess its clinical value. ? 2013 AUR.
机译：原理和目的：我们旨在对现有文献进行荟萃分析，以评估使用对比增强超声（CEUS）作为诊断工具的前列腺癌（PCa）研究的准确性。材料和方法：检索MEDLINE，EMBASE和Cochrane图书馆数据库，以查找截至2012年8月发表的相关原始文章。记录纳入研究的特征。通过使用诊断研究工具的质量评估来评估方法学质量。计算诊断比值比（DOR），敏感性，特异性以及阳性和阴性似然比（LR）的合并加权估计。构建了摘要接收器操作员特征（SROC）曲线，以计算曲线下的面积（AUC）。还进行了出版偏向分析。结果：荟萃分析包括16项研究（2624例患者）。应用了各种造影剂和成像模式。独立的随机效应摘要显示诊断值存在差异。敏感性，特异性和DOR的汇总估计分别为0.70、0.74和9.09。加权的正负LR分别为2.81和0.35，研究之间的异质性具有统计学意义（P <.001）。在阳性患者研究中，敏感性优于阳性活检组织（0.78比0.64）。 SROC图显示的AUC值为（0.82）。 Begg检验（P = .822）和Egger检验（P = .198）没有显示出版偏倚的证据。结论：CEUS是检测PCa的有前途的工具，但在目前情况下不能完全取代系统活检。必须标准化成像技术，造影剂和诊断标准。要评估其临床价值，必须进行大样本，多中心研究和高质量的前瞻性试验。 ？ 2013 AUR。

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