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首页> 外文期刊>Academic radiology >Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34).
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Pharmacokinetic analysis of malignant pleural mesothelioma-initial results of tumor microcirculation and its correlation to microvessel density (CD-34).

机译：恶性胸膜间皮瘤的药代动力学分析-肿瘤微循环的初步结果及其与微血管密度的相关性（CD-34）。

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RATIONALE AND OBJECTIVES: Malignant mesothelioma (MM) of the pleura is an aggressive and often fatal neoplasm. Because MM frequently demonstrates marked angiogenesis, it may be responsive to antiangiogenic therapy, but effective methods for selecting and monitoring of patients are further needed. We employed dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and quantitative immunohistochemistry (IHC) to characterize the microvascularity of MM using both a physiologic and ultrastructural method. MATERIALS AND METHODS: Nineteen patients diagnosed with MM were enrolled and DCE-MRI was performed before antiangiogenic treatment. For each patient, tumor regions were characterized by their DCE-MRI-derived pharmacokinetic parameters (Amp, k(ep), k(el)), which were also compared to those of normal tissue (aorta, liver, spleen, and muscle). In addition, quantitative IHC of representative samples was performed with CD-34 staining to compare the calculated microvessel density (MVD) results with DCE-MRI results. RESULTS: MM demonstrated markedly abnormal pharmacokinetic properties compared with normal tissues. Among the parameters tested, Amp was significantly different in MM (P < or = .001) compared to normal organs. Despite the observation that the MVD of mesotheliomas in this series was high compared to other tumors, DCE-MRI pharmacokinetic parameters had a moderately positive correlation with MVD (r = 0.5). CONCLUSIONS: DCE-MRI and IHC can be used in patients with MM to visualize tumor microvascularity and to characterize tumor heterogeneity. DCE-MRI and IHC results positively correlated, though moderately, but these two methods present as essential tumor biomarkers. This multimodal characterization may be useful in selecting possible tumor subtypes that would benefit from antiangiogenic therapy.
机译：理由和目的：胸膜恶性间皮瘤（MM）是一种侵袭性且通常是致命的肿瘤。由于MM经常表现出明显的血管生成，因此它可能对抗血管生成治疗有反应，但是还需要用于选择和监测患者的有效方法。我们采用了动态对比增强磁共振成像（DCE-MRI）和定量免疫组织化学（IHC）来使用生理学和超微结构方法来表征MM的微血管。材料与方法：纳入19例确诊为MM的患者，并在抗血管生成治疗之前进行DCE-MRI检查。对于每位患者，都通过其DCE-MRI衍生的药代动力学参数（Amp，k（ep），k（el））来表征肿瘤区域，并与正常组织（主动脉，肝脏，脾脏和肌肉）进行比较。此外，用CD-34染色对代表性样品进行定量IHC，以将计算出的微血管密度（MVD）结果与DCE-MRI结果进行比较。结果：与正常组织相比，MM表现出明显的异常药代动力学特性。在测试的参数中，与正常器官相比，MM的Amp显着不同（P <或= .001）。尽管观察到该系列间皮瘤的MVD高于其他肿瘤，但DCE-MRI药代动力学参数与MVD呈中等正相关（r = 0.5）。结论：DCE-MRI和IHC可用于MM患者以可视化肿瘤微血管和表征肿瘤异质性。 DCE-MRI和IHC结果虽然呈中等水平，但呈正相关，但这两种方法是必需的肿瘤生物标记物。这种多峰表征可能有助于选择可能受益于抗血管生成治疗的肿瘤亚型。

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