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首页> 外文期刊>Academic radiology >Analysis of location specific observer performance data: validated extensions of the jackknife free-response (JAFROC) method.
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Analysis of location specific observer performance data: validated extensions of the jackknife free-response (JAFROC) method.

机译：特定位置观察者性能数据的分析：折刀自由响应（JAFROC）方法的有效扩展。

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摘要

RATIONALE AND OBJECTIVES: The free-response paradigm is being increasingly used in the assessment of medical imaging systems. The currently implemented method of analyzing the data, namely jackknife free-response (JAFROC) analysis, has some validation and applicability limitations. The purpose of this work is to address these limitations. MATERIALS AND METHODS: The general principles of modality evaluation and methodology validation are reviewed. A model for simulating free-response data was used to test the statistical validity of several methods of analyzing the data. The methods differed only in the choice of the figure of merit used to quantify performance. Statistical validity was judged by investigating the behaviors of the methods under null hypothesis conditions of no difference between modalities. RESULTS: The validity of the different methods of analyzing the data was found to be dependent on the choice of figure of merit. A figure of merit is identified that accommodates abnormal images withmultiple (one or more) lesions, detections of which could have different clinical significances (weights). This figure of merit is shown to be statistically valid. An extension of the analysis to single reader interpretations of images from different modalities is also shown to be statistically valid. CONCLUSION: With the validated enhancements, JAFROC is expected to be of greater utility to users of the free-response method. The extension to single-reader interpretations should be of particular value to developers of image processing algorithms, including developers of computer-aided diagnosis algorithms.
机译：理由和目标：自由响应范例正在越来越多地用于医学成像系统的评估中。当前实施的数据分析方法，即折刀自由响应（JAFROC）分析，存在一些验证和适用性限制。这项工作的目的是解决这些限制。材料与方法：回顾了模态评估和方法论验证的一般原则。使用模拟自由响应数据的模型来测试多种分析数据方法的统计有效性。这些方法仅在选择用于量化性能的品质因数方面有所不同。通过调查在方法之间没有差异的无效假设条件下这些方法的行为来判断统计有效性。结果：发现不同的数据分析方法的有效性取决于品质因数的选择。确定了品质因数，该品质因数可容纳具有多个（一个或多个）病变的异常图像，对其进行检测可能具有不同的临床意义（权重）。该品质因数显示为在统计上有效。该分析扩展到来自不同模态的图像的单读者解释也被证明在统计上是有效的。结论：经过验证的增强功能，JAFROC有望对自由响应方法的用户发挥更大的作用。对单一阅读器解释的扩展对于图像处理算法的开发人员，包括计算机辅助诊断算法的开发人员，应该具有特殊的价值。

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