...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Academic radiology >Inhibition effects of high mechanical index ultrasound contrast on hepatic metastasis of cancer in a rat model.
【24h】

Inhibition effects of high mechanical index ultrasound contrast on hepatic metastasis of cancer in a rat model.

机译：高机械指数超声造影剂对大鼠模型肝转移的抑制作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

RATIONAL AND OBJECTIVES: The liver is the most common organ for tumor metastasis. The development of new methods to depress hepatic metastasis is of great importance in improving survival. The aim of this study was to observe the effects of high-mechanical index ultrasound contrast on hepatic metastasis of colorectal cancer. MATERIALS AND METHODS: Hepatic metastasis models were established by injecting human colon carcinoma LoVo cells into the spleens of Sprague-Dawley rats. The rats were divided into a control group, a microbubble plus ultrasound group, a simple ultrasound group, and a simple microbubble group. The ultrasound contrast agent SonoVue (1 mL/kg) was injected via the tail vein, and high-mechanical index ultrasound contrast (frequency, 1.5 MHz; mechanical index, 1.7) was performed on the spleen intermittently for 2 minutes. The animals were sacrificed after 10 days, and the sizes and number of hepatic metastases were measured and compared. Histologic pathology and splenic ultrastructure were observed. RESULTS: The number and sizes of hepatic metastases patently decreased in rats in the microbubble plus ultrasound group (P < .01). There were no obvious differences among the control group, simple ultrasound group, and simple microbubble group in hepatic metastases (P > .05). Histologic pathology showed that the number of tumor cells in the spleens decreased considerably, and massive necroses, hemorrhages, and thrombi were observed in the tumor and spleen tissues of rats in the microbubble plus ultrasound group. Transmission electron microscopy showed that the mitochondria of tumor cells and endothelial cells were clearly swelled, and there were gaps among endothelial cells and platelets aggregated in capillary vessels. CONCLUSION: This research shows that intermittent high-mechanical index ultrasound contrast may inhibit the hepatic metastasis of cancer in a rat model.
机译：合理性和目的：肝脏是最常见的肿瘤转移器官。抑制肝转移的新方法的开发对提高生存率具有重要意义。这项研究的目的是观察高机械指数超声造影对大肠癌肝转移的影响。材料与方法：通过将人结肠癌LoVo细胞注射入Sprague-Dawley大鼠的脾脏，建立肝转移模型。将大鼠分为对照组，微泡加超声组，简单超声组和简单微泡组。通过尾静脉注射超声造影剂SonoVue（1 mL / kg），并在脾脏间断进行高机械指标超声造影（频率1.5 MHz;机械指标1.7）。 10天后处死动物，并测量和比较肝转移的大小和数目。观察组织病理学和脾超微结构。结果：微泡加超声组大鼠肝转移的数量和大小明显减少（P <.01）。对照组，单纯超声组和单纯微泡组之间在肝转移方面无明显差异（P> .05）。组织病理学观察发现，微泡加超声组大鼠脾脏中肿瘤细胞数量明显减少，并且在大鼠的肿瘤和脾脏组织中观察到大量坏死，出血和血栓。透射电镜观察发现，肿瘤细胞和内皮细胞的线粒体明显肿胀，内皮细胞与毛细血管中聚集的血小板之间存在间隙。结论：这项研究表明，间歇性高机械指数超声造影可能抑制大鼠模型的肝转移。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号