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首页> 外文期刊>Academic radiology >64-slice CT perfusion imaging of pancreatic adenocarcinoma and mass-forming chronic pancreatitis.
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64-slice CT perfusion imaging of pancreatic adenocarcinoma and mass-forming chronic pancreatitis.

机译：胰腺腺癌和大量形成的慢性胰腺炎的64层CT灌注成像。

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RATIONALE AND OBJECTIVES: To investigate 64 computed tomography (CT) perfusion imaging features of patients with pancreatic cancer and mass-forming chronic pancreatitis. MATERIALS AND METHODS: Between January 2003 and April 2010, 234 patients with pancreatic mass underwent 64-CT perfusion imaging. Among them, the histopathological results of 64 patients were proven to be pancreatic adenocarcinoma and 15 patients were proven to be mass-forming chronic pancreatitis. Additionally, CT perfusion imaging was performed in 33 healthy volunteers served as controls. The slice data were processed using CT perfusion software. Perfusion parameters including time density curve, blood flow, blood volume, permeability, peak enhancement, and time to peak were recorded. RESULTS: Blood flow was 77% lower in patients with pancreatic adenocarcinoma than in controls, 48% lower in patients with mass-forming chronic pancreatitis than in controls, and 56% lower in patients with pancreatic adenocarcinoma than with mass-forming chronic pancreatitis (P < .016). Blood volume was 65% lower in pancreatic adenocarcinoma than in controls, 27% lower in mass-forming chronic pancreatitis than in controls, and 53% lower in cancer than mass-forming chronic pancreatitis (P < .016). Permeability was 559% higher in pancreatic adenocarcinoma than in controls, 821% higher in mass-forming chronic pancreatitis than in controls, and 28% lower in cancer than mass-forming chronic pancreatitis (P < .016). Peak enhancement was 27% lower and time to peak 23% longer in pancreatic adenocarcinoma than mass-forming chronic pancreatitis (P < .016). Time-density curve showed the peak of mass-forming chronic pancreatitis is earlier and higher than that of pancreatic adenocarcinoma, and the peak of mass-forming chronic pancreatitis is later and lower than that of controls. CONCLUSION: CT perfusion imaging can provide additional quantitative hemodynamic information of pancreatic adenocarcinoma and mass-forming chronic pancreatitis.
机译：理由和目的：研究64例胰腺癌和大量形成性慢性胰腺炎患者的计算机断层扫描（CT）灌注成像特征。材料与方法：在2003年1月至2010年4月之间，对234例胰腺肿块患者进行了64-CT灌注成像。其中，64例患者的组织病理学结果被证实为胰腺腺癌，15例患者被证实为肿块形成的慢性胰腺炎。另外，在33名健康志愿者中进行了CT灌注成像。使用CT灌注软件处理切片数据。记录灌注参数，包括时间密度曲线，血流量，血容量，通透性，峰增强和达到峰的时间。结果：胰腺腺癌患者的血流量比对照组低77％，形成性慢性胰腺炎的患者比对照组低48％，胰腺腺癌患者的血流比形成质量的慢性胰腺炎（P <.016）。胰腺腺癌的血容量比对照组低65％，形成质量的慢性胰腺炎比对照组低27％，癌症比形成质量的慢性胰腺炎低53％（P <.016）。胰腺腺癌的通透性比对照组高559％，成块性慢性胰腺炎的通透性比对照组高821％，癌症比成块性慢性胰腺炎的通透性低28％（P <.016）。与大量形成的慢性胰腺炎相比，胰腺腺癌的峰值增强降低了27％，到达峰值的时间延长了23％（P <.016）。时间-密度曲线显示，肿块形成的慢性胰腺炎的峰值较胰腺腺癌早且高，而肿块形成的慢性胰腺炎的峰值较对照组低且较对照组低。结论：CT灌注成像可提供胰腺腺癌和大量形成性慢性胰腺炎的定量血流动力学信息。

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