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首页> 外文期刊>Academic radiology >Hepatic enhancement in colorectal cancer: texture analysis correlates with hepatic hemodynamics and patient survival.
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Hepatic enhancement in colorectal cancer: texture analysis correlates with hepatic hemodynamics and patient survival.

机译：大肠癌的肝功能增强：质地分析与肝血流动力学和患者生存率相关。

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RATIONALE AND OBJECTIVES: Perfusion imaging of the liver has attracted interest as a potential means for earlier detection of hepatic metastases, but the techniques are complex and do not form part of routine imaging protocols. This study assesses whether the hemodynamic status of the liver of patients with colorectal cancer but apparently normal hepatic morphology is reflected by texture features within a single portal-phase contrast enhanced computed tomography (CT) image and correlates texture with overall survival. MATERIALS AND METHODS: Portal-phase CT images from 27 patients with colorectal cancer but no apparent hepatic metastases were processed using a band-pass filter that highlighted image features at different spatial frequencies. A range of parameters reflecting liver texture on filtered images were correlated against CT hepatic perfusion index (HPI) and patient survival. RESULTS: After image filtration, entropy values from hepatic regions were inversely correlated with HPI (r=-0.503978, P=.007355), and directly correlated with survival (r=0.489642, P=.009533). An entropy value below 2.0 identified four patients who died within 36 months of their CT scan with sensitivity 100% and specificity 65% (P<.03). CONCLUSION: The hemodynamic status of the liver is reflected by subtle changes in coarse texture on portal phase images that can be revealed by texture analysis. Texture analysis has the potential to identify colorectal cancer patients with an apparently normal portal phase hepatic CT but reduced survival.
机译：理由和目的：肝脏灌注成像作为早期发现肝转移的一种潜在手段已引起人们的兴趣，但该技术很复杂，并不构成常规成像方案的一部分。这项研究评估了结直肠癌患者肝脏的血流动力学状态，但显然肝形态正常，是通过单个门期对比增强计算机断层扫描（CT）图像中的纹理特征反映出来的，并且将纹理与整体存活率相关联。材料与方法：使用带通滤波器处理了27例结直肠癌但无明显肝转移的门期CT图像，该滤波器突出显示了不同空间频率的图像特征。在过滤图像上反映肝脏纹理的一系列参数与CT肝灌注指数（HPI）和患者生存率相关。结果：图像过滤后，来自肝脏区域的熵值与HPI呈负相关（r = -0.503978，P = .007355），而与生存率直接相关（r = 0.489642，P = .009533）。熵值低于2.0时，识别出四名在CT扫描后36个月内死亡的患者，其敏感性为100％，特异性为65％（P <.03）。结论：肝脏的血流动力学状态反映在门静脉期图像上粗糙纹理的细微变化，可以通过纹理分析来揭示。质地分析有可能识别出门静脉期肝CT正常但存活率降低的结直肠癌患者。

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