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首页> 外文期刊>Academic radiology >Hyperglycemia in hospitalized patients receiving corticosteroid premedication before the administration of radiologic contrast medium.
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Hyperglycemia in hospitalized patients receiving corticosteroid premedication before the administration of radiologic contrast medium.

机译：在接受放射性对比剂治疗之前接受糖皮质激素治疗的住院患者的高血糖。

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RATIONALE AND OBJECTIVES: To assess the effect of short-term corticosteroid premedication on serum glucose in hospitalized patients. MATERIALS AND METHODS: Serum glucose in adult inpatients receiving corticosteroid premedication before a radiology study was compared to serum glucose in nonpremedicated controls between May 1, 2008, and September 12, 2009. Patients were categorized by type of nonionic contrast medium (intravenous [IV] or none) and route of corticosteroid premedication (oral, IV, none). Diabetes mellitus (types I and II) was evaluated as an independent risk factor. Patients without glucose estimations before and after premedication were excluded. Results were analyzed with analysis of variance and a stepwise linear regression analysis. RESULTS: There were 390 corticosteroid premedication episodes in 390 patients; 873 examinations in 844 patients served as controls. Cohorts receiving corticosteroid premedication experienced a brief (24-48 hour) increase in mean maximum postbaseline serum glucose (IV, +81 mg/dL; oral, +70 mg/dL) that was greater than the increase in nonpremedicated controls (+46 mg/dL). Type I (+144 mg/dL) and type II (+108 mg/dL) diabetics had a greater elevation than nondiabetics (+34 mg/dL). Both corticosteroid premedication (IV, P = .02; oral, P = .01) and diabetes mellitus (type I, P = .0002; type II, P < .0001) were significant independent risk factors of hyperglycemia. The use of nonionic intravascular contrast medium was not (P = .7). There was no significant difference between IV and oral premedication (P = .6), or type I and type II diabetes mellitus (P = .8). CONCLUSIONS: Diabetes mellitus (type I and type II) and corticosteroid premedication (oral and IV) are significant independent risk factors for the development of brief hyperglycemia near the time of inpatient radiology studies.
机译：理由和目的：评估短期皮质类固醇激素药物治疗对住院患者血糖的影响。材料与方法：在放射学研究之前，接受皮质类固醇药物治疗的成年住院患者的血糖与未接受药物治疗的对照组的血糖在2008年5月1日至2009年9月12日之间进行了比较。按非离子造影剂类型（静脉内[IV]或没有）和糖皮质激素的预防用药途径（口服，静脉注射，无）。糖尿病（I型和II型）被评估为独立的危险因素。排除在用药前后没有葡萄糖估计的患者。通过方差分析和逐步线性回归分析对结果进行分析。结果：390例患者中有390例接受糖皮质激素治疗;在844例患者中进行了873次检查作为对照。接受皮质类固醇用药的队列人群基线后平均最大血糖（IV，+ 81 mg / dL;口服，+ 70 mg / dL）短暂增加（24-48小时），大于未接受药物治疗的对照组的增加（+46 mg / dL）。 I型糖尿病（+144 mg / dL）和II型糖尿病（+108 mg / dL）的糖尿病患者的身高比非糖尿病患者（+34 mg / dL）高。糖皮质激素的处方（IV，P = .02;口服，P = .01）和糖尿病（I型，P = .0002; II型，P <.0001）都是高血糖的重要独立危险因素。没有使用非离子血管内造影剂（P = 0.7）。静脉用药和口服用药之间（P = .6）或I型和II型糖尿病（P = .8）之间无显着差异。结论：糖尿病（I型和II型）和糖皮质激素的预治疗（口服和IV型）是在住院放射学研究临近时发生短暂高血糖的重要独立危险因素。

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