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首页> 外文期刊>Academic radiology >Coregistered ventilation and perfusion SPECT using krypton-81m and Tc-99m-labeled macroaggregated albumin with multislice CT utility for prediction of postoperative lung function in non-small cell lung cancer patients.
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Coregistered ventilation and perfusion SPECT using krypton-81m and Tc-99m-labeled macroaggregated albumin with multislice CT utility for prediction of postoperative lung function in non-small cell lung cancer patients.

机译：使用k-81m和Tc-99m标记的巨集白蛋白与多层CT实用程序进行的配准通气和灌注SPECT预测非小细胞肺癌患者的术后肺功能。

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RATIONALE AND OBJECTIVE: Co-registered SPECT and CT imaging (SPECT-CT) has potential for more precise evaluation of regional pulmonary function and may be useful for prediction of postoperative lung function in non-small cell lung cancer (NSCLC) patients. The purpose of the present study was to prospectively assess the capability of co-registered SPECT-CT using krypton-81m (Kr-81m) and technetium-99m-labeled macroaggregated albumin (Tc-99m MAA) for prediction of postoperative lung function of NSCLC patients compared with SPECT and planar imaging. MATERIALS AND METHODS: Sixty consecutive patients considered candidates for lung resection underwent 16-slice CT, ventilation and perfusion scintigraphy with SPECT examinations, and preoperative and postoperative measurement of FEV(1)%. In each subject, SPECT and CT data were automatically fused by using commercially available software. Each postoperative FEV(1)% value was predicted from uptakes of Kr-81m and Tc-99m MAA within total and resected lungs. Then, reproducibility coefficients and the limits of agreement between actual and each predicted postoperative lung function were statistically assessed. RESULTS: Reproducibility coefficients of SPECT-CT (Kr-81m: 5.1%, Tc-99m MAA: 5.2%) were smaller than those of SPECT and planar image using Kr-81m (SPECT: 7.4%, planar image: 12.1%) and using Tc-99m MAA (SPECT: 7.2%, planar image: 11.8%). The limits of agreement for SPECT-CT (Kr-81m: 3.3 +/- 10.5%, Tc-99m MAA: 5.4 +/- 11.0%) were also smaller than that of SPECT and planar image and small enough for clinical purposes. CONCLUSIONS: Co-registered SPECT-CT using Kr-81m and Tc-99m MAA was able to more reproducibly and accurately predict postoperative lung function compared with SPECT and planar imaging.
机译：理由和目的：共同注册的SPECT和CT成像（SPECT-CT）有潜力更精确地评​​估区域肺功能，并且可能对非小细胞肺癌（NSCLC）患者的术后肺功能预测有用。本研究的目的是前瞻性评估使用k 81m（Kr-81m）和tech 99m标记的巨集白蛋白（Tc-99m MAA）共同注册的SPECT-CT预测NSCLC术后肺功能的能力患者与SPECT和平面成像相比。材料与方法：连续60例考虑行肺切除的患者接受了16层CT扫描，通气和灌注闪烁显像，并进行SPECT检查，术前和术后FEV（1）％的测量。在每个受试者中，SPECT和CT数据通过使用市售软件自动融合。每个术后FEV（1）％的值是根据全肺和切除肺中Kr-81m和Tc-99m MAA的摄取预测的。然后，统计学评估可重复性系数和实际与预期的术后肺功能之间的一致性极限。结果：SPECT-CT（Kr-81m：5.1％，Tc-99m MAA：5.2％）的再现系数小于使用Kr-81m（SPECT：7.4％，平面图像：12.1％）和SPECT-CT的再现系数。使用Tc-99m MAA（SPECT：7.2％，平面图像：11.8％）。 SPECT-CT（Kr-81m：3.3 +/- 10.5％，Tc-99m MAA：5.4 +/- 11.0％）的协议范围也比SPECT和平面图像的协议范围小，并且足够用于临床目的。结论：与SPECT和平面成像相比，使用Kr-81m和Tc-99m MAA共同注册的SPECT-CT能够更重现和准确地预测术后肺功能。

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