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首页> 外文期刊>Academic radiology >Registering histologic and MR images of prostate for image-based cancer detection.
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Registering histologic and MR images of prostate for image-based cancer detection.

机译：配准前列腺的组织学和MR图像以进行基于图像的癌症检测。

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RATIONALE AND OBJECTIVES: Needle biopsy is currently the only way to confirm prostate cancer. To increase prostate cancer diagnostic rate, needles are expected to be deployed at suspicious cancer locations. High-contrast magnetic resonance (MR) imaging provides a powerful tool for detecting suspicious cancerous tissues. To do this, MR appearances of cancerous tissue should be characterized and learned from a sufficient number of prostate MR images with known cancer information. However, ground-truth cancer information is only available in histologic images. Therefore it is necessary to warp ground-truth cancerous regions in histological images to MR images by a registration procedure. The objective of this article is to develop a registration technique for aligning histological and MR images of the same prostate. MATERIAL AND METHODS: Five pairs of histological and T2-weighted MR images of radical prostatectomy specimens are collected. For each pair, registration is guided by two sets of correspondences that can be reliably established on prostate boundaries and internal salient bloblike structures of histologic and MR images. RESULTS: Our developed registration method can accurately register histologic and MR images. It yields results comparable to manual registration, in terms of landmark distance and volume overlap. It also outperforms both affine registration and boundary-guided registration methods. CONCLUSIONS: We have developed a novel method for deformable registration of histologic and MR images of the same prostate. Besides the collection of ground-truth cancer information in MR images, the method has other potential applications. An automatic, accurate registration of histologic and MR images actually builds a bridge between in vivo anatomical information and ex vivo pathologic information, which is valuable for various clinical studies.
机译：理由和目的：穿刺活检是目前确认前列腺癌的唯一方法。为了提高前列腺癌的诊断率，预期将针头部署在可疑的癌症位置。高对比度磁共振（MR）成像为检测可疑的癌组织提供了强大的工具。为此，应特征化癌组织的MR外观，并从足够数量的具有已知癌症信息的前列腺MR图像中获知。但是，仅在组织学图像中可以获得真实的癌症信息。因此，有必要通过配准程序将组织学图像中的真相癌变区域变形为MR图像。本文的目的是开发一种对齐技术，用于对齐同一前列腺的组织学图像和MR图像。材料与方法：收集5对前列腺癌根治术标本的组织学和T2加权MR图像。对于每一对，配准由两组对应关系指导，可以在前列腺边界和组织学和MR图像的内部显着斑点样结构上可靠建立。结果：我们开发的配准方法可以准确配准组织学和MR图像。就界标距离和体积重叠而言，它产生的结果可媲美手动注册。它还优于仿射配准和边界引导配准方法。结论：我们开发了一种新颖的方法来对同一前列腺的组织学图像和MR图像进行可变形配准。除了在MR图像中收集真实的癌症信息外，该方法还有其他潜在应用。组织学和MR图像的自动，准确配准实际上在体内解剖信息和离体病理信息之间架起了一座桥梁，这对于各种临床研究都具有重要意义。

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