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首页> 外文期刊>Academic radiology >In search of biologic correlates for liver texture on portal-phase CT.
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In search of biologic correlates for liver texture on portal-phase CT.

机译：在门期CT上寻找肝脏纹理的生物学相关因素。

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RATIONALE AND OBJECTIVES: The acceptance of computer-assisted diagnosis (CAD) in clinical practice has been constrained by the scarcity of identifiable biologic correlates for CAD-based image parameters. This study aims to identify biologic correlates for computed tomography (CT) liver texture in a series of patients with colorectal cancer. MATERIALS AND METHODS: In 28 patients with colorectal cancer, total hepatic perfusion (THP), hepatic arterial perfusion, and hepatic portal perfusion (HPP) were measured using perfusion CT. Hepatic glucose use was also determined from positron emission tomography (PET) and expressed as standardized uptake value (SUV). A hepatic phosphorylation fraction index (HPFI) was determined from both SUV and THP. These physiologic parameters were correlated with CAD parameters namely hepatic densitometry, selective-scale, and relative-scale texture features in apparently normal areas of portal-phase hepatic CT. RESULTS: For patients without liver metastases, a relative-scale texture parameter correlated inversely with SUV (r = -0.587, P = .007) and, positively with THP (r = 0.512, P = .021) and HPP (r = 0.451, P = .046). However, this relative texture parameter correlated most significantly with HPFI (r = -0.590, P = .006). For patients with liver metastases, although not significant an opposite trend was observed between these physiologic parameters and relative texture features (THP: r < -0.4, HPFI: r > 0.35). CONCLUSION: Total hepatic blood flow and glucose metabolism are two distinct but related biologic correlates for liver texture on portal phase CT, providing a rationale for the use of hepatic texture analysis as a indicator for patients with colorectal cancer.
机译：理由和目的：由于基于CAD的图像参数缺乏可识别的生物学相关因素，因此临床实践对计算机辅助诊断（CAD）的接受受到了限制。这项研究的目的是确定一系列结肠直肠癌患者的计算机断层扫描（CT）肝纹理的生物学相关性。材料与方法：在28例结直肠癌患者中，使用灌注CT测量了总肝灌注（THP），肝动脉灌注和肝门灌注（HPP）。肝葡萄糖的使用也由正电子发射断层扫描（PET）确定，并表示为标准化摄取值（SUV）。从SUV和THP确定肝磷酸化分数指数（HPFI）。这些生理参数与CAD参数相关，即门静脉期肝脏CT的正常区域中的肝脏密度测定法，选择性尺度和相对尺度的纹理特征。结果：对于无肝转移的患者，相对尺度纹理参数与SUV（r = -0.587，P = .007）呈负相关，与THP（r = 0.512，P = .021）和HPP（r = 0.451）呈正相关。 ，P = .046）。但是，该相对纹理参数与HPFI最为相关（r = -0.590，P = .006）。对于有肝转移的患者，尽管这些生理参数和相对纹理特征之间没有明显的相反趋势（THP：r <-0.4，HPFI：r> 0.35）。结论：肝总血流和葡萄糖代谢是两个不同但相关的生物学相关因素，与门静脉CT上的肝纹理有关，为使用肝纹理分析作为结直肠癌患者的指标提供了理论依据。

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