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首页> 外文期刊>Academic radiology >3D and 2D delayed-enhancement magnetic resonance imaging for detection of myocardial infarction: preclinical and clinical results.
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3D and 2D delayed-enhancement magnetic resonance imaging for detection of myocardial infarction: preclinical and clinical results.

机译：用于心肌梗塞检测的3D和2D延迟增强磁共振成像：临床前和临床结果。

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RATIONALE AND OBJECTIVES: The purpose was to verify whether myocardial viability can be detected by a delayed enhancement magnetic resonance imaging (MRI) approach using a rapid three-dimensional inversion-recovery fast low-angle shot (3D IR-FLASH) sequence in a preclinical and clinical setting. MATERIALS AND METHODS: Nonreperfused myocardial infarctions were induced in eight minipigs. Both the pigs and 15 patients with suspected myocardial infarction underwent MRI using a rapid 3D IR-FLASH sequence and a two-dimensional IR-FLASH sequence as the reference standard. RESULTS: In the pigs, a total of 52 segments with myocardial infarction were identified with both sequences and there was good agreement in transmurality of 99.5%. The infarction volume determined with the 3D IR-FLASH in the animal study (2.4 +/- 1.5 cm(3)) showed a good correlation with the histomorphometrically determined volume using triphenyltetrazolium chloride (2.3 +/- 1.2 cm(3), r = 0.98, P < .001) and the two-dimensional IR-FLASH sequence (2.3 +/- 1.4 cm(3), r = 0.99, P < .001). Eleven of 15 patients were found to have myocardial infarction in 37 myocardial segments with both sequences and there was a good agreement in transmurality of 98.8%. There was also a good correlation in the clinical study between the 3D and 2D sequences (6.9 +/- 6.7 cm(3) vs. 6.8 +/- 6.5 cm(3), r = 0.98, P < .001). In Bland-Altman analysis there was no significant under- or overestimation of the myocardial infarction volume using the 3D IR-FLASH sequence in comparison to the two-dimensional reference standard in both the preclinical and clinical study. The contrast-to-noise ratios were not significantly different between 3D and 2D sequences in the animal (34.7 +/- 1.5 vs. 33.8 +/- 2.6; P = .51) and clinical study (31.4 +/- 12.5 vs. 36.7 +/- 11.5; P .31). The breathhold time for the 3D IR-FLASH sequence in the clinical study (20.4 +/- 2.2 s) was significantly shorter than that of the 2D IR-FLASH sequence (190.1 +/- 20.8 s, P < .001). CONCLUSIONS: The rapid 3D IR-FLASH sequence detects myocardial infarction with high accuracy and allows a relevant reduction in acquisition time.
机译：理由和目的：目的是验证是否可以通过在临床前使用快速三维反转恢复快速低角度拍摄（3D IR-FLASH）序列的延迟增强磁共振成像（MRI）方法检测心肌活力和临床环境。材料与方法：八只小型猪诱发了未再灌注的心肌梗塞。使用快速3D IR-FLASH序列和二维IR-FLASH序列作为参考标准，对猪和15例怀疑有心肌梗塞的患者进行MRI。结果：在猪中，两个序列共鉴定出52个心肌梗死节段，透壁率达99.5％。在动物研究中使用3D IR-FLASH确定的梗塞体积（2.4 +/- 1.5 cm（3））显示与使用三苯基四唑氯化物（2.3 +/- 1.2 cm（3））的组织形态测定的体积有很好的相关性，r = 0.98，P <.001）和二维IR-FLASH序列（2.3 +/- 1.4 cm（3），r = 0.99，P <.001）。发现15例患者中有11例在37个心肌节段都有这两种序列的心肌梗塞，透壁率的一致性达到98.8％。在3D和2D序列之间的临床研究中也有很好的相关性（6.9 +/- 6.7 cm（3）对6.8 +/- 6.5 cm（3），r = 0.98，P <.001）。在Bland-Altman分析中，与二维参考标准相比，在临床前和临床研究中，使用3D IR-FLASH序列均无明显低估或高估心肌梗塞体积。动物的3D和2D序列之间的对比噪声比没有显着差异（34.7 +/- 1.5与33.8 +/- 2.6; P = 0.51）和临床研究（31.4 +/- 12.5与36.7） +/- 11.5; P .31）。在临床研究中，3D IR-FLASH序列的屏气时间（20.4 +/- 2.2 s）显着小于2D IR-FLASH序列的屏气时间（190.1 +/- 20.8 s，P <.001）。结论：快速的3D IR-FLASH序列可以高精度检测心肌梗塞，并可以相应地减少采集时间。

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