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首页> 外文期刊>Acta biomaterialia >Poly-epsilon-caprolactone/hydroxyapatite for tissue engineering scaffold fabrication via selective laser sintering.
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Poly-epsilon-caprolactone/hydroxyapatite for tissue engineering scaffold fabrication via selective laser sintering.

机译：聚ε-己内酯/羟基磷灰石，用于通过选择性激光烧结制造组织工程支架。

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摘要

Rapid prototyping (RP) techniques are becoming more popular for fabricating tissue engineering (TE) scaffolds owing to their advantages over conventional methods, such as the ability to fabricate scaffolds with predetermined interconnected networks without the use of organic solvents. A versatile RP technique, selective laser sintering (SLS), offers good user control of scaffold microstructure by adjusting the process parameters. This research focuses on a the use of biocomposite material, consisting of poly-epsilon-caprolactone (PCL) and hydroxyapatite (HA), to fabricate TE scaffolds using SLS. Biocomposite blends with different percentage weights of HA were physically blended and sintered to assess their suitability for fabrication via SLS. Optimal sintering conditions for the powders were achieved by varying parameters such as laser power and scan speed. Studies of the sintered specimen morphology were performed by scanning electron microscopy. Thermogravimetric analysis confirmed the homogeneity ofthe biocomposite blend. Simulated body fluid (SBF) samples show the formation of hydroxy carbonate apatite, as a result of soaking HA in a SBF environment. Cell culture experiment showed that Saos-2 cells were able to live and replicate on the fabricated scaffolds. The results show the favorable potential of PCL/HA biocomposite as TE scaffolds that are fabricated via SLS.
机译：由于快速原型技术（RP）与常规方法相比的优势（例如无需使用有机溶剂即可制造具有预定互连网络的支架的能力），因此在制造组织工程（TE）支架方面正变得越来越流行。一种通用的RP技术，选择性激光烧结（SLS），可通过调整工艺参数为用户提供对支架微结构的良好控制。这项研究的重点是利用由聚ε-己内酯（PCL）和羟基磷灰石（HA）组成的生物复合材料，通过SLS制备TE支架。将具有不同百分比的HA的生物复合共混物进行物理混合和烧结，以评估其是否适合通过SLS制造。通过改变诸如激光功率和扫描速度之类的参数来获得粉末的最佳烧结条件。通过扫描电子显微镜对烧结样品的形态进行研究。热重分析证实了生物复合混合物的均质性。模拟体液（SBF）样品显示，由于将HA浸泡在SBF环境中，导致形成了碳酸羟基磷灰石。细胞培养实验表明，Saos-2细胞能够在装配好的支架上存活并复制。结果表明PCL / HA生物复合材料作为通过SLS制备的TE支架具有良好的潜力。

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