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首页> 外文期刊>Acta biomaterialia >Effect of phosphate functional groups on the calcification capacity of acrylic hydrogels.
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Effect of phosphate functional groups on the calcification capacity of acrylic hydrogels.

机译：磷酸官能团对丙烯酸水凝胶钙化能力的影响。

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The incorporation of negatively charged groups into the structure of synthetic polymers is frequently advocated as a method for enhancing their calcification capacity required in orthopedic and dental applications. However, the results reported by various research groups are rather contentious, since inhibitory effects have also been observed in some studies. In the present study, phosphate groups were introduced in poly(2-hydroxyethyl methacrylate) (PHEMA) by copolymerization with 10% mol of either mono(2-acryloyloxyethyl) phosphate (MAEP) or mono(2-methacryloyloxyethyl) phosphate (MMEP). Incubation of these hydrogels for determined durations (1-9 weeks) in a simulated body fluid (SBF) solution induced deposition of calcium phosphate (CaP) deposits of whitlockite type. After 9 weeks, the amount of calcium deposited on the phosphate-containing polymers was four times lower than that found on PHEMA, as determined by X-ray photoelectron spectroscopy (XPS). Samples of copolymer HEMA-MAEP were implanted subcutaneously in rats and evaluated after 9 weeks. No CaP deposits could be detected on the copolymer by XPS or energy dispersive X-ray spectroscopy, while PHEMA samples were massively calcified. It was concluded that the presence of phosphate groups decreased the calcification capacity of the hydrogels, and that in the conditions of this study, the phosphate groups had an inhibitory effect on the deposition of CaP phases on HEMA-based hydrogels.
机译：经常提倡将带负电的基团掺入合成聚合物的结构中，作为增强矫形和牙科应用所需的钙化能力的方法。但是，各个研究小组报告的结果颇具争议，因为在某些研究中还观察到了抑制作用。在本研究中，通过与10％摩尔的单（2-丙烯酰氧基乙基）磷酸酯（MAEP）或单（2-甲基丙烯酰氧基乙基）磷酸酯（MMEP）共聚，将磷酸基团引入聚甲基丙烯酸2-羟乙酯（PHEMA）中。将这些水凝胶在确定的持续时间内（1-9周）在模拟体液（SBF）溶液中孵育，从而导致生成了辉锰矿型磷酸钙（CaP）沉积物。 9周后，通过X射线光电子能谱（XPS）测定，沉积在含磷酸盐的聚合物上的钙含量比在PHEMA上发现的钙含量低四倍。将共聚物HEMA-MAEP的样品皮下植入大鼠体内，并在9周后进行评估。通过XPS或能量色散X射线光谱法无法在共聚物上检测到CaP沉积物，而PHEMA样品则被大量钙化。结论是磷酸根基团的存在降低了水凝胶的钙化能力，在本研究条件下，磷酸根基团对基于HEMA的水凝胶对CaP相的沉积具有抑制作用。

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