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首页> 外文期刊>Acta biomaterialia >Structure-function relationships and source-to-ground distance in electrospun polycaprolactone.
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Structure-function relationships and source-to-ground distance in electrospun polycaprolactone.

机译：电纺聚己内酯的结构-功能关系和源到地距离。

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摘要

The strength of electrospun scaffolds has direct relevance to their function within tissue engineering. We characterized the effects of source-to-ground distance on the mechanical properties of electrospun poly(epsilon-caprolactone) (PCL). Source-to-ground distances of 10, 15 and 20 cm, solids concentrations of 12 and 18 wt.% and mandrel rotation surface speeds of 0-12 m s(-1) were utilized. Tensile tests evaluated elastic modulus, tensile strength and elongation at failure. Scanning electron microscopy provided morphology and quantified fiber alignment. Increased source-to-ground distance yielded a microstructure allowing greater fiber rearrangement under load, tripling the observed tensile strength. Increases in rotational speed generally increased fiber alignment and strength at high but not low to moderate speeds. As fiber is quickly pulled out of a comparatively gentle falling process, collision with neighboring fibers moving at different speeds and in different directions can occur. The source-to-ground distance influences these collisions and thus has critical implications for microstructure and biocompatibility. In larger diameter (18 wt.% PCL), heavily point-bonded fibers (produced using a shorter, 10 cm source-to-ground distance), elongation at failure in the aligned direction increases dramatically due to severe localized necking. These specimens show only half of the tensile strength (from 2.6 to 4.5 MPa) and a dramatic increase (from 94% to 503%) in elongation at failure vs. a longer 20 cm source-to-ground distance. Strains of several hundred per cent are accompanied by periodic necking of large-diameter fibers in which microstructural failure appears to occur in a sequential manner involving an equilibrium between localized strain in the tensile direction and anisotropic point bonding that locally resists strain.
机译：电纺支架的强度与其在组织工程中的功能直接相关。我们表征了源到地距离对电纺聚（ε-己内酯）（PCL）机械性能的影响。源到地的距离为10、15和20 cm，固体浓度为12和18 wt。％，芯轴旋转表面速度为0-12 m s（-1）。拉伸试验评估了弹性模量，抗张强度和断裂伸长率。扫描电子显微镜提供形态学和定量的纤维排列。源到地距离的增加产生了一个微观结构，该微观结构允许在负载下进行更大的纤维重排，从而使观察到的拉伸强度提高了三倍。旋转速度的提高通常会提高纤维的排列和强度，但在高速但不低至中等速度时会提高。随着光纤从相对缓慢的下降过程中快速拔出，可能会与以不同速度和不同方向移动的相邻光纤发生碰撞。源到地的距离影响这些碰撞，因此对微观结构和生物相容性具有关键意义。在较大直径（PCL为18 wt。％）的情况下，严重的点粘结纤维（使用较短的10 cm源到地距离生产）中，由于严重的局部颈缩，沿对齐方向破坏时的伸长率急剧增加。这些样品仅显示出一半的抗拉强度（从2.6到4.5 MPa），断裂伸长率显着提高（从94％到503％），而从源到地的距离更长（20 cm）。数百％的应变伴随着大直径纤维的周期性缩颈，在该缩颈中，微观结构破坏似乎是依次发生的，涉及在拉伸方向上的局部应变与局部抵抗应变的各向异性点粘结之间的平衡。

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