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首页> 外文期刊>Acta biomaterialia >Intrinsic porosity of calcium phosphate cements and its significance for drug delivery and tissue engineering applications.
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Intrinsic porosity of calcium phosphate cements and its significance for drug delivery and tissue engineering applications.

机译：磷酸钙水泥的固有孔隙率及其在药物输送和组织工程应用中的意义。

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One key point in the field of tissue engineering and drug delivery is to provide materials with an adequate porosity. Many events, including nutrient and waste exchange in scaffolds for tissue engineering, as well as the drug-loading capacity and control of the release rate in drug delivery systems, are controlled by the size, shape and distribution of the pores in the material. Calcium phosphate cements (CPCs) possess an intrinsic porosity that is highly suited for these applications, and this porosity can be controlled by modifying some processing parameters. The objective of this work was to characterize and control the intrinsic porosity of alpha-tricalcium phosphate (alpha-TCP) cements, and to investigate its role against adsorption of bovine serum albumin (BSA). Cements with different percentages of open porosity (35-55%) were prepared by modifying the liquid-to-powder ratio. In addition, two different TCP particles were used to yield cements with specific surface areas of approximately 20 and approximately 37m(2)g(-1). Mercury porosimetry analysis on the set cements showed in most cases a bimodal pore size distribution which varied with the processing parameters and affected differently the adsorption and penetration of BSA. The peak occurring at larger pore dimensions controlled the penetration of BSA and was ascribed to the voids generated in between crystal aggregates, while the peak appearing at lower pore sizes was believed to be due to the intercrystallite voids within aggregates. It was found that, at the concentrations studied, the high intrinsic porosity in CPC does not ensure protein penetration unless there is an adequate pore size distribution.
机译：组织工程和药物输送领域的一个关键点是为材料提供足够的孔隙率。许多事件，包括材料中孔的大小，形状和分布，控制着组织工程支架中的养分和废物交换，以及载药能力和药物输送系统中释放速率的控制。磷酸钙水泥（CPC）具有非常适合这些应用的固有孔隙率，可以通过修改某些加工参数来控制该孔隙率。这项工作的目的是表征和控制α-磷酸三钙（α-TCP）水泥的固有孔隙率，并研究其对牛血清白蛋白（BSA）吸附的作用。通过改变液粉比来制备具有不同孔隙率百分比（35-55％）的水泥。此外，使用两种不同的TCP颗粒来生产比表面积约为20和37m（2）g（-1）的水泥。固化水泥的汞孔隙率分析表明，在大多数情况下，双峰孔径分布随工艺参数而变化，并且对BSA的吸附和渗透影响不同。在较大孔尺寸处出现的峰控制了BSA的渗透，并归因于晶体聚集体之间产生的空洞，而在较小孔尺寸处出现的峰被认为是由于聚集体中的晶间空洞所致。发现在所研究的浓度下，除非有足够的孔径分布，否则CPC中的高固有孔隙率无法确保蛋白质渗透。

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