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首页> 外文期刊>Acta biomaterialia >Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: characterization and in vivo evaluation.
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Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: characterization and in vivo evaluation.

机译：通过仿生过程制备的多孔钛和硅取代羟基磷灰石生物改性材料：表征和体内评估。

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摘要

Porous titanium with a pore size of 150-600 microm and a porosity of 67% was prepared by fiber sintering. The porous titanium had a complete three-dimensional (3D) interconnected structure and a high yield strength of 100 MPa. Si-substituted hydroxyapatite (Si-HA) was coated on the surface by a biomimetic process to improve the surface bioactivity. X-ray diffraction results showed that Si-HA coating was not well crystallized. New bone tissue was found in the uncoated porous titanium after 2 weeks of implantation and a significant increase (p<0.05) in the bone ingrowth rate (BIR) was found after 4 weeks of implantation, indicating the good osteoconductivity of the porous structure. The HA-coated and Si-HA-coated porous titanium exhibited a significantly higher BIR than the uncoated titanium at all intervals, highlighting the better surface bioactivity and osteoconductivity of the HA- and Si-HA coatings. Also, the Si-HA-coated porous titanium demonstrated a significantly higher BIR than the HA-coated porous titanium, showing that silicon plays an active role in the surface bioactivity. For Si-HA-coated porous titanium, up to 90% pore area was covered by new bone tissue after 4 weeks of implantation in cortical bone. In the bone marrow cavity, the pore spaces were filled with bone marrow, displaying that the interconnected pore structure could provide a channel for body fluid. It was concluded that both the 3D interconnected pore structure and the Si-HA coating contributed to the high BIR.
机译：通过纤维烧结制备具有150-600微米的孔尺寸和67％的孔隙率的多孔钛。多孔钛具有完整的三维（3D）互连结构和100 MPa的高屈服强度。通过仿生过程将Si-取代的羟基磷灰石（Si-HA）涂覆在表面上，以提高表面生物活性。 X射线衍射结果表明Si-HA涂层没有很好地结晶。植入2周后，未涂覆的多孔钛中发现了新的骨组织，植入4周后，发现了骨长入率（BIR）的显着增加（p <0.05），表明该多孔结构具有良好的骨传导性。在所有间隔下，HA涂层和Si-HA涂层的多孔钛均显示出比未涂层的钛明显更高的BIR，突出显示了HA-涂层和Si-HA涂层的更好的表面生物活性和骨传导性。而且，Si-HA涂覆的多孔钛表现出比HA涂覆的多孔钛显着更高的BIR，表明硅在表面生物活性中起积极作用。对于Si-HA涂层的多孔钛，皮层骨植入4周后，新的骨组织覆盖了高达90％的孔面积。在骨髓腔中，孔隙空间充满了骨髓，表明相互连接的孔隙结构可以为体液提供通道。结论是3D互连孔结构和Si-HA涂层均有助于提高BIR。

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