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首页> 外文期刊>Acta biomaterialia >In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects.
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In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects.

机译：在体内和体外评估柔性棉状纳米复合材料作为复杂缺陷的骨替代材料。

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摘要

The easy clinical handling and applicability of biomaterials has become a focus of materials research due to rapidly increasing time and cost pressures in the public health sector. The present study assesses the in vitro and in vivo performance of a flexible, mouldable, cottonwool-like nanocomposite based on poly(lactide-co-glycolide) and amorphous tricalcium phosphate nanoparticles (PLGA/TCP 60:40). Immersion in simulated body fluid showed exceptional in vitro bioactivity for TCP-containing fibres (mass gain: 18%, 2 days, HAp deposition). Bone regeneration was quantitatively investigated by creating four circular non-critical-size calvarial defects in New Zealand White rabbits. The defects were filled with the easy applicable cottonwool-like PLGA/TCP fibres or PLGA alone. Porous bovine-derived mineral (Bio-Oss) was used as a positive control and cavities left empty served as a negative control. The area fraction of newly formed bone (4 weeks implantation) was significantly increased for TCP-containing fibres compared to pure PLGA (histological and micro-computed tomographic analysis). A spongiosa-like structure of the newly formed bone tissue was observed for PLGA/TCP nanocomposites, whereas Bio-Oss-treated defects afforded a solid cortical bone.
机译：由于公共卫生领域中时间和成本压力的迅速增加，生物材料的易于临床处理和适用性已成为材料研究的重点。本研究评估了基于聚（丙交酯-乙交酯）和无定形磷酸三钙纳米颗粒（PLGA / TCP 60:40）的柔性，可模制，棉状纳米复合材料的体外和体内性能。浸入模拟体液对含TCP的纤维表现出优异的体外生物活性（质量增加：18％，2天，HAp沉积）。通过在新西兰白兔中创建四个圆形的非临界大小的颅骨缺损，对骨的再生进行了定量研究。缺陷由容易使用的棉状PLGA / TCP纤维或单独的PLGA填充。多孔牛源性矿物质（Bio-Oss）被用作阳性对照，而空洞则用作阴性对照。与纯PLGA（组织学和显微计算机断层分析）相比，含TCP的纤维新形成的骨头（植入4周）的面积分数显着增加。对于PLGA / TCP纳米复合材料，观察到了新形成的骨组织的海绵状结构，而经Bio-Oss处理的缺损提供了坚实的皮质骨。

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