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首页> 外文期刊>Acta biomaterialia >Enhancement of nerve regeneration along a chitosan nanofiber mesh tube on which electrically polarized beta-tricalcium phosphate particles are immobilized.
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Enhancement of nerve regeneration along a chitosan nanofiber mesh tube on which electrically polarized beta-tricalcium phosphate particles are immobilized.

机译：沿着固定有电极化的β-磷酸三钙颗粒的壳聚糖纳米纤维网管增强神经再生。

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The ability of beta-tricalcium phosphate (beta-TCP) particles to store electric charge was confirmed by thermally stimulated depolarization current measurement as well as surface potential measurement. The efficacy of stored electrical charge on beta-TCP particles in enhancing nerve regeneration was evaluated. Bridge grafting was performed into sciatic nerve defects in Wistar rats with the following tubes: chitosan mesh tubes; chitosan mesh tubes on which beta-TCP particles with or without electrical polarization treatment had been immobilized (polarized and non-polarized tubes, respectively). As a control, isografts were used. Both motor and sensory nerve function as well as electrophysiological recovery progressed with time in each group. Immunofluorescence revealed rapider nerve regeneration in the polarized tube group compared with the non-polarized tube group. The axon density and axon area in the polarized tube group were significantly greater than those in the chitosan mesh tube and non-polarized group, and showed no significant differences from the control group. These results suggest that the stored charge on electrically polarized beta-TCP particles immobilized on chitosan mesh tubes may enhance nerve regeneration to the same extent as isografting.
机译：β-磷酸三钙（β-TCP）颗粒存储电荷的能力已通过热刺激的去极化电流测量以及表面电势测量得到证实。评估了存储在β-TCP颗粒上的电荷增强神经再生的功效。用以下试管对Wistar大鼠的坐骨神经缺损进行桥骨移植。固定有经过或未经电极化处理的β-TCP粒子的壳聚糖网管（分别为极化和非极化管）。作为对照，使用了同种异体移植物。每组中运动神经和感觉神经功能以及电生理恢复均随时间而发展。免疫荧光显示，与非极化管组相比，极化管组的神经再生更快。偏光管组的轴突密度和轴突面积显着大于壳聚糖网管和非偏光组，且与对照组无显着差异。这些结果表明，固定在壳聚糖网状管上的电极化β-TCP颗粒上的电荷储存可以与异种移植一样增强神经再生。

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