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首页> 外文期刊>Acta biomaterialia >Photopolymerizable and injectable polyurethanes for biomedical applications: synthesis and biocompatibility.
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Photopolymerizable and injectable polyurethanes for biomedical applications: synthesis and biocompatibility.

机译：用于生物医学应用的可光聚合和可注射聚氨酯：合成和生物相容性。

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摘要

Two types of photopolymerizable and injectable polyurethane acrylates (PUAs), based on poly(propylene glycol) or poly(caprolactone diol) and hydroxyethyl methacrylate, were synthesized and characterized in order to obtain information regarding their use as an injectable material for biomedical applications. Structural characteristics of the biomaterials, including the degree of phase separation, were evaluated by Fourier transform infrared spectroscopy. The viscosities of the obtained biomaterials make them suitable for injection, molding and photopolymerization using visible light, as demonstrated by the injection test. The cured polymers had mechanical properties comparable to those of certain soft tissues, such as skin. An in vitro cell-polyurethane cytotoxicity study was carried out with mesenchymal stem cells from rat tibias and femurs. The proliferation/viability of the cells in the presence of the synthesized material was assessed by the MTT assay, collagen synthesis analysis and the expression of alkaline phosphatase. The results that were obtained through the in vitro tests indicated that PUAs are cytocompatible. The in vivo experiments were correlated with the in vitro tests and showed low levels of toxicity for the obtained biomaterials. Histology cross-sections showed that the biomaterials induced no significant inflammatory reaction. Our study demonstrates the potential for using synthesized photocurable polyurethanes in biomedical applications. Furthermore, the obtained injectable polymer systems employ minimally invasive procedures and can be molded in situ before photopolymerization with visible light.
机译：合成并表征了两种基于聚丙二醇或聚己内酯二醇和甲基丙烯酸羟乙酯的可光聚合和注射用聚氨酯丙烯酸酯（PUA），以获取有关其用作生物医学应用可注射材料的信息。通过傅立叶变换红外光谱法评估了生物材料的结构特征，包括相分离程度。如注射测试所示，所获得的生物材料的粘度使其适于使用可见光进行注射，成型和光聚合。固化的聚合物具有与某些软组织（如皮肤）相当的机械性能。对来自大鼠胫骨和股骨的间充质干细胞进行了体外细胞-聚氨酯细胞毒性研究。通过MTT测定，胶原合成分析和碱性磷酸酶的表达来评估在合成材料存在下细胞的增殖/存活力。通过体外测试获得的结果表明，PUA具有细胞相容性。体内实验与体外实验相关，并且显示出所获得的生物材料的毒性低。组织学横截面显示，生物材料未引起明显的炎症反应。我们的研究表明了在生物医学应用中使用合成的光固化聚氨酯的潜力。此外，所获得的可注射聚合物系统采用了微创方法，并且可以在用可见光进行光聚合之前就地模制。

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