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首页> 外文期刊>Acta biomaterialia >New generation of chitosan-encapsulated ZnO quantum dots loaded with drug: synthesis, characterization and in vitro drug delivery response.
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New generation of chitosan-encapsulated ZnO quantum dots loaded with drug: synthesis, characterization and in vitro drug delivery response.

机译：载有药物的壳聚糖封装的ZnO量子点的新一代：合成，表征和体外药物传递反应。

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The objective of the study is to describe a new approach of combining quantum dots technology with anti-cancer drug therapy. In this regard, we communicate the preliminary research on the synthesis of blue-light emitting ZnO quantum dots (QDs) combined with biodegradable chitosan (N-acetylglucosamine) for tumor-targeted drug delivery. The results presented here indicate that the proposed new generation of QDs loaded with anti-cancer agents and encapsulated with biocompatible polymer represent a potential platform to deliver tumor-targeted drugs and document the delivery process, if desired. Non-toxic water-dispersed ZnO QDs with long-term fluorescence stability were synthesized by a chemical hydrolysis method, encapsulated with chitosan and loaded with anti-cancer drug. Chitosan enhanced the stability of the QDs because of the hydrophilicity and cationic charge of chitosan. The study points toward the application of water-dispersed ZnO QDs with long-term fluorescence stability for design of new drug release carrier.
机译：该研究的目的是描述一种将量子点技术与抗癌药物治疗相结合的新方法。在这方面，我们传达了结合可生物降解的壳聚糖（N-乙酰氨基葡萄糖）的蓝光发射ZnO量子点（QD）的合成的初步研究，用于肿瘤靶向药物的递送。此处提供的结果表明，如果需要，建议的新一代QD载有抗癌药并封装有生物相容性聚合物，代表了潜在的平台，可以递送靶向肿瘤的药物并记录递送过程。通过化学水解的方法合成了具有长期荧光稳定性的无毒的水分散ZnO量子点，将其包裹在壳聚糖中并负载抗癌药物。壳聚糖由于壳聚糖的亲水性和阳离子电荷而提高了量子点的稳定性。研究指向具有长期荧光稳定性的水分散ZnO量子点在新药物释放载体设计中的应用。

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