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首页> 外文期刊>Acta biomaterialia >Cytocompatibility of poly(acrylonitrile-co-N-vinyl-2-pyrrolidone) membranes with human endothelial cells and macrophages.
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Cytocompatibility of poly(acrylonitrile-co-N-vinyl-2-pyrrolidone) membranes with human endothelial cells and macrophages.

机译：聚（丙烯腈-co-N-乙烯基-2-吡咯烷酮）膜与人内皮细胞和巨噬细胞的细胞相容性。

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摘要

Polyacrylonitrile modified with N-vinyl-2-pyrrolidone (NVP) shows good hemocompatibility. This work, which aims to evaluate the cytocompatibility of membranes fabricated from poly(acrylonitrile-co-N-vinyl-2-pyrrolidone) (PANCNVP), studied the adhesion of macrophages and endothelial cell (EC) cultures. It was found that PANCNVP membranes with higher NVP content decreased the adhesion of both macrophages and ECs. Compared with polyacrylonitrile and tissue culture polystyrene control, however, these PANCNVP membranes promoted the proliferation of ECs. Furthermore, the viability of ECs cultured on the PANCNVP membrane surfaces was also relatively competitive. Both static and dynamic water contact angle measurements were conducted to explain the nature of cell adhesion to the PANCNVP membranes. On the basis of these results and the phenomena of water swelling and water states reported previously, it was presumed that the coexistence of large amounts of bound water and free water induced by NVP moieties are responsible for the lower adhesion and better function of cells adhering to the PANCNVP membranes.
机译：用N-乙烯基-2-吡咯烷酮（NVP）改性的聚丙烯腈显示出良好的血液相容性。这项工作旨在评估由聚（丙烯腈-co-N-乙烯基-2-吡咯烷酮）（PANCNVP）制成的膜的细胞相容性，研究了巨噬细胞和内皮细胞（EC）培养物的粘附性。发现具有较高NVP含量的PANCNVP膜降低了巨噬细胞和EC的粘附。与聚丙烯腈和组织培养的聚苯乙烯对照相比，这些PANCNVP膜促进了EC的增殖。此外，在PANCNVP膜表面培养的EC的生存能力也相对较强。进行了静态和动态水接触角测量，以解释细胞粘附到PANCNVP膜的性质。根据这些结果以及先前报道的水肿现象和水状态，可以推测，NVP部分诱导的大量结合水和游离水的共存是造成细胞黏附力降低和黏附功能增强的原因。 PANCNVP膜。

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