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首页> 外文期刊>Acta biomaterialia >Effect of nitinol wire surface properties on albumin adsorption.
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Effect of nitinol wire surface properties on albumin adsorption.

机译：镍钛合金丝表面性能对白蛋白吸附的影响。

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摘要

The superelastic, shape memory alloy nitinol ( approximately 50% nickel and approximately 50% titanium) is an important medical device material used for stent applications. However, the role specific surfaces properties have in protein adsorption remain controversial. In this study the effects of nitinol wire surface roughness, hydrophobicity and elemental composition upon albumin adsorption are investigated. In particular, we demonstrate that the technique of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in the so-called surface mode can be used for the direct detection of albumin on the wire surfaces. In addition, albumin adsorbing to the wires was determined by using (125)I-labelled albumin. Albumin was detected on all wire samples. Surface roughness and hydrophobicity appeared to have no effect on albumin adsorption. There was however a clear correlation between the surface nickel and oxygen concentration and the amount of albumin adsorbed. Samples with higher levels of nickel and less oxygen in the surface oxide layer of the wires showed increased albumin adsorption, which could lead to improved biocompatibility. However, nickel is a toxic substance and can cause many adverse effects on humans, and thus nitinol with a slightly enriched surface nickel concentration that does not exhibit nickel release may have potential as a medical device material.
机译：超弹性的形状记忆合金镍钛诺（约50％的镍和约50％的钛）是用于支架应用的重要医疗器械材料。然而，特定表面性质在蛋白质吸附中的作用仍存在争议。在这项研究中，研究了镍钛诺线材表面粗糙度，疏水性和元素组成对白蛋白吸附的影响。特别是，我们证明了所谓的表面模式下的基质辅助激光解吸/电离飞行时间质谱技术可用于直接检测金属丝表面上的白蛋白。另外，通过使用（125）I-标记的白蛋白测定吸附到电线上的白蛋白。在所有电线样品上均检测到白蛋白。表面粗糙度和疏水性似乎对白蛋白吸附没有影响。但是，表面镍和氧的浓度与吸附白蛋白的量之间存在明显的相关性。导线表面氧化物层中镍含量较高且氧含量较低的样品显示出白蛋白吸附增加，这可能导致生物相容性提高。但是，镍是有毒物质，会对人体造成许多不利影响，因此镍镍合金表面镍浓度稍高而不会释放镍，则可能具有作为医疗器械材料的潜力。

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