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首页> 外文期刊>Acta biomaterialia >Porous NiTi for bone implants: A review.
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Porous NiTi for bone implants: A review.

机译：用于骨植入物的多孔镍钛合金：综述。

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摘要

NiTi foams are unique among biocompatible porous metals because of their high recovery strain (due to the shape-memory or superelastic effects) and their low stiffness facilitating integration with bone structures. To optimize NiTi foams for bone implant applications, two key areas are under active study: synthesis of foams with optimal architectures, microstructure and mechanical properties; and tailoring of biological interactions through modifications of pore surfaces. This article reviews recent research on NiTi foams for bone replacement, focusing on three specific topics: (i) surface modifications designed to create bio-inert porous NiTi surfaces with low Ni release and corrosion, as well as bioactive surfaces to enhance and accelerate biological activity; (ii) in vitro and in vivo biocompatibility studies to confirm the long-term safety of porous NiTi implants; and (iii) biological evaluations for specific applications, such as in intervertebral fusion devices and bone tissue scaffolds. Possiblefuture directions for bio-performance and processing studies are discussed that could lead to optimized porous NiTi implants.
机译：NiTi泡沫在生物相容性多孔金属中是独特的，因为它们的高回复应变（由于形状记忆或超弹性效应）和低刚度有助于与骨结构整合。为使NiTi泡沫最适合骨植入物应用，正在积极研究两个关键领域：合成具有最佳结构，微观结构和机械性能的泡沫;通过修饰孔表面来调整生物相互作用。本文回顾了有关用于替代骨骼的NiTi泡沫的最新研究，重点关注三个特定主题：（i）表面改性，旨在产生具有低Ni释放和腐蚀的生物惰性多孔NiTi表面，以及具有生物活性的表面，以增强和加速生物活性; （ii）体外和体内生物相容性研究，以证实多孔NiTi植入物的长期安全性; （iii）针对特定应用的生物学评估，例如在椎间融合器和骨组织支架中。讨论了生物性能和加工研究的未来可能方向，这些方向可能会导致优化的多孔NiTi植入物。

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