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首页> 外文期刊>Acta biomaterialia >Manipulation of process parameters to achieve different ternary phase microparticle configurations.
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Manipulation of process parameters to achieve different ternary phase microparticle configurations.

机译：操纵工艺参数以实现不同的三元相微粒构型。

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摘要

Ternary phase microparticles of poly(D,L-lactide-co-glycolide) (50:50), poly(L-lactide) and poly(caprolactone) were fabricated through a one-step solvent evaporation technique. The purpose of this study was to examine the effects of various process parameters on the final configuration (i.e. polymer distribution and dimensions) of these composite microparticles and, subsequently, propose their mechanism of formation. Particle morphologies and configurations were determined using scanning electron microscopy, polymer dissolution tests and Raman mapping. It was found that a starting polymer solution prepared below the cloud point and an increased oil to water ratio will facilitate polymer configurations close to thermodynamic equilibrium, which is dictated by the interfacial energies of the components. By varying the polymer mass ratio or adjusting the precipitation rate, through stirring speed and oil to water ratio, a wide range of microparticles with different core-shell dimensions and embedded particulate sizes can also be fabricated. At the same time, lowering the polymer solution concentration and increasing the stirring speed may result in smaller microparticles. Correlation of these process parameters with the final composite particle morphology was thus established. This understanding should allow the controlled fabrication of ternary phase composite microparticles through a single step solvent evaporation technique.
机译：通过一步溶剂蒸发技术制备了聚（D，L-丙交酯-乙交酯-乙交酯）（50:50），聚（L-丙交酯）和聚己内酯的三元微粒。这项研究的目的是检查各种工艺参数对这些复合微粒的最终构型（即聚合物分布和尺寸）的影响，然后提出其形成机理。使用扫描电子显微镜，聚合物溶解测试和拉曼作图确定颗粒的形态和构型。发现在浊点以下制备的起始聚合物溶液和增加的油水比将促进接近于热力学平衡的聚合物构型，这由组分的界面能决定。通过改变聚合物的质量比或调节沉淀速率，通过搅拌速度和油水比，还可以制造出具有不同核壳尺寸和包埋颗粒尺寸的各种微粒。同时，降低聚合物溶液浓度和提高搅拌速度可导致更小的微粒。因此，建立了这些工艺参数与最终复合颗粒形态的相关性。这种理解应允许通过一步溶剂蒸发技术来控制三元复合微粒的制造。

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