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首页> 外文期刊>Acta biomaterialia >A novel potentiometric method for the determination of real crosslinking ratio of poly(aspartic acid) gels.
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A novel potentiometric method for the determination of real crosslinking ratio of poly(aspartic acid) gels.

机译：一种测定聚天冬氨酸凝胶的实际交联比的新型电位法。

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摘要

In order to obtain nontoxic functional polymer gels for biomedical applications, chemically crosslinked poly(aspartic acid) gels have been prepared using 1,4-diaminobutane as crosslinker. The presence of COOH and amino groups on the network chains renders these gels pH sensitive. Due to the specific hydrophobic-hydrophilic balance, these gels show a significant volume transition at a well-defined pH close to the pK value of uncrosslinked poly(aspartic acid). Since the magnitude of volume change critically depends on the degree of crosslinking, it is an important task to determine the topological characteristics of these networks. A novel method based on potentiometric acid-base titration has been developed to assess the crosslinking ratio, excluding physical crosslinks and entanglements. It turned out that only 25% of all crosslinker molecules forms real crosslinks between the poly(aspartic acid) chains; the rest react with one of its functional groups and forms short pendant side chains. At a nominal crosslinking ratio of 0.1, the number average molecular mass between crosslinks is found to be M(c) = 2300.
机译：为了获得用于生物医学应用的无毒功能性聚合物凝胶，已经使用1，4-二氨基丁烷作为交联剂制备了化学交联的聚（天冬氨酸）凝胶。网络链上COOH和氨基的存在使这些凝胶对pH敏感。由于特定的疏水-亲水平衡，这些凝胶在接近未交联的聚天冬氨酸的pK值的明确定义的pH值下显示出明显的体积转变。由于体积变化的幅度主要取决于交联度，因此确定这些网络的拓扑特征是一项重要的任务。已开发出一种基于电位酸碱滴定的新方法来评估交联比，但不包括物理交联和缠结。结果表明，所有交联剂分子中只有25％形成了聚（天冬氨酸）链之间的真正交联;其余的与其官能团之一反应并形成短的侧链侧链。在标称交联比为0.1时，发现交联之间的数均分子量为M（c）= 2300。

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