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首页> 外文期刊>Acta biomaterialia >In vitro calcification of chemically functionalized carbon nanotubes.
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In vitro calcification of chemically functionalized carbon nanotubes.

机译：化学功能化碳纳米管的体外钙化。

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Bone is composed of two phases. The organic phase is made of collagen fibrils assembled in broad fibers acting as a template for mineralization. The mineral phase comprises hydroxyapatite (HAP) crystals grown between and inside the collagen fibers. We have developed a biomimetic material using functionalized carbon nanotubes as scaffold to initiate in vitro mineralization. Biomimetic formation of HAP was performed on single-walled carbon nanotubes (SWCNTs) which have been grafted with carboxylic groups. Two types of nanotubes, HiPco(R) and Carbon Solutions(R), were oxidized via various acidic processes, leading to five different groups of carboxylated nanotubes, fully characterized by physical methods (thermogravimetric analysis, attenuated total reflectance infrared spectroscopy and X-ray photoelectron spectroscopy). All samples were dispersed in ultra-pure water and incubated for 2weeks in a synthetic body fluid, in order to induce the calcification of the SWCNTs. Scanning electron microscopy (SEM) and energy-dispersive X-ray analysis studies showed that Ca(2+) and PO(4)(3-) ions were deposited as round-shaped nodules (calcospherites) on the carboxylated SWCNTs. Fourier transform infrared and Raman spectroscopic studies confirmed the HAP formation, and image analysis made on SEM pictures showed that calcospherites and carboxylated SWCNTs were packed together. The size of calcospherites thus obtained in vitro from the HiPco(R) series was close to that issued from calcospherites observed in vivo. Functionalization of SWCNTs with carboxylic groups confers the capacity to induce calcification similar to woven bone.
机译：骨骼由两个阶段组成。有机相是由胶原蛋白原纤维制成的，这些胶原蛋白原纤维被组装成宽阔的纤维，用作矿化的模板。矿物相包含在胶原纤维之间和内部生长的羟磷灰石（HAP）晶体。我们已经开发出一种仿生材料，使用功能化的碳纳米管作为支架来启动体外矿化作用。 HAP的仿生形成是在已接有羧基的单壁碳纳米管（SWCNT）上进行的。两种纳米管通过各种酸性过程被氧化，形成五种不同的羧基化纳米管，并通过物理方法（热重分析，衰减全反射红外光谱和X射线）进行了全面表征光电子能谱）。将所有样品分散在超纯水中，并在合成体液中孵育2周，以诱导SWCNT的钙化。扫描电子显微镜（SEM）和能量色散X射线分析研究表明，Ca（2+）和PO（4）（3-）离子以圆形结节（方解石）的形式沉积在羧化SWCNT上。傅里叶变换红外光谱和拉曼光谱研究证实了HAP的形成，并且在SEM图像上进行的图像分析表明，钙沸石和羧化SWCNT堆积在一起。这样从HiPco系列中体外获得的钙沸石的尺寸接近于体内观察到的钙沸石的尺寸。具有羧基的SWCNT的功能化赋予了诱导钙化的能力，类似于编织骨。

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