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Light-curable polymer/calcium phosphate nanocomposite glue for bone defect treatment.

机译:光固化聚合物/磷酸钙纳米复合胶,用于骨缺损治疗。

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摘要

Light-curable, methacrylate-based resins are clinically used for complex defect repair in dentistry (Heliobond). The present study investigates how such easy-to-apply polymers may be used on a much broader range of applications, particularly for gluing wet bone. We investigate the significantly improved adhesion of the polymer to wet bone surfaces in a close to in vivo setup using freshly cut cow hip bone as a model. The use of a reactive filler (20 wt.% amorphous, glassy calcium phosphate nanoparticles, a-CaP) allows for combination of the properties of the polymer (strength; light-curing) and the reactive filler (recrystallization of amorphous CaP to hydroxyapatite within minutes). This filler alone has been earlier suggested for use as an injectable bone cement since it reacts under in vivo conditions within 10-15 min. Our study transfers this reactivity into a composite, thus using the reactive CaP phase to establish an improved adhesion of the composite to wet bone surfaces. Additional in vitro bioactivity tests, compressive and tensile strength suggest use of such light-curable nanocomposites for complex-shaped load-bearing implant materials and fracture repair.
机译:临床上将光固化的基于甲基丙烯酸酯的树脂用于牙科的复杂缺陷修复(Heliobond)。本研究调查了这种易于应用的聚合物如何在更广泛的应用领域中使用,尤其是用于胶合湿骨。我们以刚切开的牛髋骨为模型,在接近体内的条件下研究了聚合物对湿骨表面的显着改善的粘附力。使用反应性填料(20 wt。%的非晶态玻璃状磷酸钙钙纳米粒子,a-CaP)可将聚合物的特性(强度;光固化)与反应性填料(非晶态CaP重结晶为羟基磷灰石)结合使用分钟)。早先有人建议将此填​​充剂单独用作注射用骨水泥,因为它在体内条件下会在10-15分钟内发生反应。我们的研究将这种反应性转移到复合材料中,从而使用反应性CaP相来建立复合材料与湿骨表面的附着力。另外的体外生物活性测试,抗压强度和拉伸强度表明,将这种可光固化的纳米复合材料用于复杂形状的承重植入物材料和骨折修复。

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