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首页> 外文期刊>Acta biomaterialia >Influence of lactose addition to gentamicin-loaded acrylic bone cement on the kinetics of release of the antibiotic and the cement properties.
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Influence of lactose addition to gentamicin-loaded acrylic bone cement on the kinetics of release of the antibiotic and the cement properties.

机译：添加庆大霉素的丙烯酸骨水泥中乳糖的添加对抗生素释放动力学和水泥特性的影响。

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摘要

The purpose of this study was to characterize a poly(methyl methacrylate) bone cement that was loaded with the antibiotic gentamicin sulphate (GS) and lactose, which served to modulate the release of GS from cement specimens. The release of GS when the cement specimens were immersed in phosphate-buffered saline at 37 degrees Celsius was determined spectrophotometrically. The microstructure, porosity, density, tensile properties and flexural properties of the cements were determined before and after release of GS. A kinetics model of the release of GS from the cement that involved a coupled mechanism based on dissolution/diffusion processes and an initial burst effect was proposed. Dissolution assay results showed that drug elution was controlled by a diffusion mechanism which can be modulated by lactose addition. Density values and mechanical properties (tensile strength, flexural strength, elastic modulus and fracture toughness) were reduced by the increased porosity resulting from lactose addition, but maintained acceptable values for the structural functions of bone cement. The present results suggest that lactose-modified, gentamicin-loaded acrylic bone cements are potential candidates for use in various orthopaedic and dental applications.
机译：这项研究的目的是表征聚甲基丙烯酸甲酯骨水泥，其中装载了硫酸庆大霉素硫酸盐（GS）和乳糖，以调节GS从水泥样品中的释放。用分光光度法测定了将水泥样品浸入37摄氏度的磷酸盐缓冲盐水中时GS的释放。在释放GS之前和之后测定水泥的微观结构，孔隙率，密度，拉伸性能和挠曲性能。提出了从水泥释放GS的动力学模型，该模型涉及基于溶解/扩散过程和初始破裂效应的耦合机理。溶出度测定结果表明，药物洗脱受扩散机制控制，扩散机制可通过添加乳糖来调节。由于添加乳糖引起的孔隙率增加，密度值和机械性能（拉伸强度，弯曲强度，弹性模量和断裂韧性）降低，但仍保持了骨水泥结构功能的可接受值。目前的结果表明，乳糖改性，庆大霉素负载的丙烯酸骨水泥是潜在的候选物，可用于各种矫形和牙科应用。

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