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首页> 外文期刊>Acta biomaterialia >Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology.
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Green processing of porous chitin structures for biomedical applications combining ionic liquids and supercritical fluid technology.

机译：结合离子液体和超临界流体技术对生物医学应用的多孔甲壳质结构进行绿色加工。

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摘要

The application of green chemistry principles in the processing of materials for advanced technologies is a steadily increasing field of research. In this work porous chitin-based materials were developed by combining the processing of chitin using ionic liquids (ILs) as a green solvent together with the use of supercritical fluid technology (SCF) as clean technology. Chitin was dissolved in 1-butyl-3-imidazolium acetate, followed by regeneration of the polymer in ethanol in specific moulds. The IL was removed using Soxhlet extraction and successive steps of extraction with SCF using carbon dioxide/ethanol ratios of 50/50 and 70/30. The developed porous chitin-based structures (ChIL) can be classified as mesoporous materials, with very low density and high porosity. The cytotoxicity of ChIL extracts was investigated using L929 fibroblast-like cells, and the results demonstrated that the produced materials have extremely low cytotoxicity levels. Therefore, the findings suggest that the porous chitin structures may be potential candidates for a number of biomedical applications, including tissue engineering.
机译：绿色化学原理在先进技术材料处理中的应用是一个稳定增长的研究领域。在这项工作中，通过将使用离子液体（IL）作为绿色溶剂的几丁质处理与使用超临界流体技术（SCF）作为清洁技术相结合，开发了基于多孔几丁质的材料。将几丁质溶于乙酸1-丁基-3-咪唑鎓中，然后在特定模具中在乙醇中再生聚合物。使用索格利特萃取法去除IL，然后使用二氧化碳/乙醇比为50/50和70/30的SCF连续萃取步骤。所开发的基于甲壳质的多孔结构（ChIL）可以被归类为中孔材料，具有非常低的密度和高的孔隙率。使用L929成纤维细胞样细胞研究了ChIL提取物的细胞毒性，结果表明所生产的材料具有极低的细胞毒性水平。因此，研究结果表明，多孔几丁质结构可能是许多生物医学应用（包括组织工程）的潜在候选者。

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