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首页> 外文期刊>Acta biomaterialia >Solvothermal synthesis of cobalt ferrite nanoparticles loaded on multiwalled carbon nanotubes for magnetic resonance imaging and drug delivery.
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Solvothermal synthesis of cobalt ferrite nanoparticles loaded on multiwalled carbon nanotubes for magnetic resonance imaging and drug delivery.

机译：溶剂热合成多壁碳纳米管上负载的铁氧体钴纳米颗粒，用于磁共振成像和药物递送。

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摘要

Multiwalled carbon nanotube (MWCNT)/cobalt ferrite (CoFe(2)O(4)) magnetic hybrids were synthesized by a solvothermal method. The reaction temperature significantly affected the structure of the resultant MWCNT/CoFe(2)O(4) hybrids, which varied from 6nm CoFe(2)O(4) nanoparticles uniformly coated on the nanotubes at 180 degrees C to agglomerated CoFe(2)O(4) spherical particles threaded by MWCNTs and forming necklace-like nanostructures at 240 degrees C. Based on the superparamagnetic property at room temperature and high hydrophilicity, the MWCNT/CoFe(2)O(4) hybrids prepared at 180 degrees C (MWCNT/CoFe(2)O(4)-180) were further investigated for biomedical applications, which showed a high T(2) relaxivity of 152.8 Fe mM(-1)s(-1) in aqueous solutions, a significant negative contrast enhancement effect on cancer cells and, more importantly, low cytotoxicity and negligible hemolytic activity. The anticancer drug doxorubicin (DOX) can be loaded onto the hybrids and subsequently released in a sustained and pH-responsive way. The DOX-loaded hybrids exhibited notable cytotoxicity to HeLa cancer cells due to the intracellular release of DOX. These results suggest that MWCNT/CoFe(2)O(4)-180 hybrids may be used as both effective magnetic resonance imaging contrast agents and anticancer drug delivery systems for simultaneous cancer diagnosis and chemotherapy.
机译：通过溶剂热法合成了多壁碳纳米管（MWCNT）/钴铁氧体（CoFe（2）O（4））磁性杂化物。反应温度显着影响所得的MWCNT / CoFe（2）O（4）杂化物的结构，其变化范围是从6nm CoFe（2）O（4）纳米颗粒均匀地涂在180摄氏度的纳米管上到团聚的CoFe（2） O（4）球形颗粒由MWCNT穿线并在240摄氏度下形成项链状纳米结构。基于室温下的超顺磁性和高亲水性，MWCNT / CoFe（2）O（4）杂化物在180摄氏度下制备（ MWCNT / CoFe（2）O（4）-180）进一步研究了生物医学应用，它显示出152.8 Fe mM（-1）s（-1）在水溶液中的高T（2）弛豫性，显着的负对比对癌细胞的增强作用，更重要的是低细胞毒性和可忽略的溶血活性。可以将抗癌药阿霉素（DOX）加载到杂种上，然后以持续且对pH敏感的方式释放。负载DOX的杂种由于细胞内释放DOX而对HeLa癌细胞表现出明显的细胞毒性。这些结果表明，MWCNT / CoFe（2）O（4）-180杂种既可以用作有效的磁共振成像造影剂，也可以用作同时进行癌症诊断和化疗的抗癌药物递送系统。

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