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首页> 外文期刊>Acta biomaterialia >Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: a comparative in vivo study in rabbits.
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Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: a comparative in vivo study in rabbits.

机译：MgCa0.8合金螺钉的生物力学测试和降解分析：兔体内比较研究。

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The aim of this study was to compare the biomechanical properties of degradable magnesium calcium alloy (MgCa0.8) screws and commonly used stainless steel (S316L) screws and to assess the in vivo degradation behavior of MgCa0.8. MgCa0.8 screws (n=48) and S316L screws (n=32) were implanted into both tibiae of 40 adult rabbits for a follow-up of 2, 4, 6 and 8 weeks. This resulted in a testing group of MgCa0.8 (n=12) and S316L (n=8) screws for each follow-up. Uniaxial pull-out tests were carried out in an MTS 858 Mini Bionix at a rate of 0.1 mm s(-1). For degradation analysis of MgCa0.8 in vivo micro-computed tomography (muCT) was performed to determine the volume of metal alloy remaining. Retrieved MgCa0.8 screws were analysed for degradation by determination of weight changes, scanning electron microscopy and energy dispersive X-ray analyses. No significant differences could be noted between the pull-out forces of MgCa0.8 and S316L 2 weeks after surgery (P=0.121). Six weeks after surgery the pull-out force of MgCa0.8 decreased slightly. In contrast, the S316L pull-out force increased with time. Thus, significantly higher pull-out values were detected for S316L from 4 weeks on (P<0.001). The volume and weight of MgCa0.8 gradually reduced. A corrosion layer, mainly composed of oxygen, magnesium, calcium and phosphorus, formed on the implants. Since MgCa0.8 showed good biocompatibility and biomechanical properties, comparable with those of S316L in the first 2-3 weeks of implantation, its application as a biodegradable implant is conceivable.
机译：这项研究的目的是比较可降解镁钙合金（MgCa0.8）螺钉和常用不锈钢（S316L）螺钉的生物力学性能，并评估MgCa0.8在体内的降解行为。将MgCa0.8螺钉（n = 48）和S316L螺钉（n = 32）植入40只成年兔的胫骨中，进行2、4、6和8周的随访。这导致了每次随访的MgCa0.8（n = 12）和S316L（n = 8）螺钉测试组。在MTS 858 Mini Bionix中以0.1 mm s（-1）的速率进行单轴拉拔测试。为了进行MgCa0.8的降解分析，在体内进行了微计算机断层扫描（muCT），以确定残留的金属合金的体积。通过确定重量变化，扫描电子显微镜和能量色散X射线分析来分析回收的MgCa0.8螺钉的降解情况。术后2周，MgCa0.8和S316L的拉出力之间没有显着差异（P = 0.121）。术后六周，MgCa0.8的拉拔力略有下降。相反，S316L的拔出力随时间增加。因此，从4周开始检测到S316L的拔出值明显更高（P <0.001）。 MgCa0.8的体积和重量逐渐减小。在植入物上形成腐蚀层，主要由氧，镁，钙和磷组成。由于MgCa0.8具有良好的生物相容性和生物力学性能，可与植入前2-3周内的S316L媲美，因此可以设想将其用作可生物降解的植入物。

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