• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Supercritical carbon dioxide processed resorbable polymer nanocomposite bone graft substitutes.
【24h】

Supercritical carbon dioxide processed resorbable polymer nanocomposite bone graft substitutes.

机译：超临界二氧化碳处理的可吸收聚合物纳米复合材料骨移植替代物。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The development of synthetic bone graft substitutes is an intense area of research due to the complications associated with the harvest of autogenous bone and concerns about the supply of allogenic bone. Porous resorbable polymers have been used extensively in hard tissue engineering applications, but currently lack load-bearing capacity. Supercritical carbon dioxide (scCO(2)) processing is used as a novel method to simultaneously impart a porous structure and disperse a nano-clay in a resorbable polymer matrix suitable for load-bearing applications. Porous resorbable polylactic acid (PLA)/cloisite clay nanocomposite constructs prepared using scCO(2) processing exhibit a 2.5-fold increase in compressive strength compared with pure polymer constructs. The resulting mechanical properties are comparable with human cancellous and cortico-cancellous bone. In addition to the significant improvements in mechanical properties, the nanocomposite constructs display a biocompatibility greater than that of polystyrene culture plate controls. Furthermore, calcium phosphate-rich deposits could clearly be seen on the surface of the constructs, as well as at the center of the cultured constructs, indicating that osteoblasts are able to penetrate the porous network of the nanocomposite constructs. Cellular infiltration of these constructs is important for their in vivo use as bone graft substitutes. The diameter of the pores suggests that these constructs would also support neovascularization, which is integral for nutrient transport.
机译：由于与自体骨的收获相关的复杂性以及对同种异体骨供应的关注，合成骨移植替代物的开发是研究的热点领域。多孔可吸收聚合物已广泛用于硬组织工程应用中，但目前缺乏承重能力。超临界二氧化碳（scCO（2））处理用作一种新颖的方法，可同时赋予多孔结构并将纳米粘土分散在适用于承重应用的可吸收聚合物基体中。与纯聚合物结构相比，使用scCO（2）处理制备的多孔可吸收聚乳酸（PLA）/硅酸盐粘土纳米复合材料结构显示出2.5倍的抗压强度。产生的机械性能与人的松质骨和皮质松质骨相当。除了机械性能的显着改善外，纳米复合材料构造物还显示出比聚苯乙烯培养板对照更大的生物相容性。此外，可以在构建体的表面以及培养的构建体的中心清楚地看到富含磷酸钙的沉积物，这表明成骨细胞能够穿透纳米复合构建体的多孔网络。这些构建体的细胞浸润对于它们在体内用作骨移植替代物很重要。孔的直径表明这些构造也将支持新血管形成，这对于营养物运输是必不可少的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号