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首页> 外文期刊>Acta biomaterialia >Effects of strontium in modified biomaterials.
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Effects of strontium in modified biomaterials.

机译：锶在改性生物材料中的作用。

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Strontium (Sr) plays a special role in bone remodelling, being associated with both the stimulation of bone formation and a reduction in bone resorption. Thus, the modification of biomaterials by partial or full substitution by Sr is expected to increase both bioactivity and biocompatibility. However, such effects have to be studied individually. Although no phase transition was found in Sr-substituted hydroxyapatite (Sr-HA), Sr-containing calcium silicate (Sr-CS) or Sr-containing borosilicate (Sr-BS), their biological performance was substantially affected by changes in the physico-chemical properties and Sr content of the materials. Three distinct outcomes were found for the presence of Sr: (1) increased HA solubility; (2) no significant effect on the degradation rate of CS; (3) apparent inhibition of the otherwise rapid degradation of BS. In each case the released Sr affected osteoblast proliferation and alkaline phosphatase activity, with clear evidence that an optimum Sr dose exists. Such chemical and biological variations must be disentangled for the behaviour to be properly understood and materials design to be advanced.
机译：锶（Sr）在骨重塑中起特殊作用，与刺激骨形成和减少骨吸收有关。因此，通过Sr的部分或全部取代对生物材料的改性有望提高生物活性和生物相容性。但是，必须单独研究这种影响。尽管在Sr取代的羟基磷灰石（Sr-HA），含Sr的硅酸钙（Sr-CS）或含Sr的硼硅酸盐（Sr-BS）中未发现相变，但是它们的生物学性能受到物理-化学变化的影响。材料的化学性质和Sr含量。对于Sr的存在，发现了三个不同的结果：（1）HA溶解度增加; （2）对CS的降解率无明显影响; （3）明显抑制了BS的迅速降解。在每种情况下，释放的Sr都会影响成骨细胞的增殖和碱性磷酸酶活性，有明确的证据表明存在最佳的Sr剂量。必须理清此类化学和生物学变化，以便正确理解其行为并改进材料设计。

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