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首页> 外文期刊>Acta biomaterialia >Submicron sized ultra-high molecular weight polyethylene wear particle analysis from revised SB Charite III total disc replacements.
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Submicron sized ultra-high molecular weight polyethylene wear particle analysis from revised SB Charite III total disc replacements.

机译：经修订的SB Charite III总盘替代品的亚微米级超高分子量聚乙烯磨损颗粒分析。

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Submicron sized particles are frequently observed in retrieved total hip and knee periprosthetic tissues and appear to be critical in the activation of the phagocytic inflammatory response. In this paper the concentration, size and shape of ultra-high molecular weight polyethylene (UHMWPE) wear particles between 0.05 and 2.00mum were determined after isolation from periprosthetic tissues from retrieved lumbar SB Charite III total disc replacements (TDR) using scanning electron microscopy (SEM). For comparison, UHMWPE wear particles were isolated from gamma-radiation-air sterilized total hip arthroplasty (THA) revision tissues. The mean concentration of UHMWPE particles in TDR tissues was 1.6x10(9)g(-1)tissue (range 1.3-2.0), which was significantly lower than the concentration of 2.3x10(9)g(-1) THA revision tissue (range 1.8-3.2) (P=0.03). The mean particle size (equivalent circular diameter: TDR, 0.46mum; THA 0.53mum, P=0.60) and mean shape were comparable between TDR and THA (aspect ratio: TDR, 1.89; THA, 1.99, P=0.35; roundness: TDR, 0.58; THA, 0.56, P=0.35). However, the TDR particles tended to be smaller and more round. Although no correlations were found between visible damage to the UHMWPE core and the concentration or shape of the UHMWPE particles, a positive correlation was found between increasing particle size and increasing rim penetration of the TDR core (P=0.04). The presence of UHMWPE particles of similar size and shape in TDR tissue, albeit lower in concentration, might explain why, unlike THA, pain rather than osteolysis is the major reason for revision surgery.
机译：在回收的整个髋关节和膝关节假体周围组织中经常观察到亚微米大小的颗粒，并且在吞噬性炎症反应的激活中起关键作用。本文使用扫描电子显微镜从回收的腰椎SB Charite III总椎间盘置换物（TDR）中分离出假体周围组织，确定了0.05至2.00μm的超高分子量聚乙烯（UHMWPE）磨损颗粒的浓度，大小和形状（ SEM）。为了进行比较，从伽马射线-空气消毒的全髋关节置换术（THA）修复组织中分离了UHMWPE磨损颗粒。 TDR组织中UHMWPE颗粒的平均浓度为1.6x10（9）g（-1）组织（范围1.3-2.0），显着低于2.3x10（9）g（-1）THA修订组织的浓度（范围1.8-3.2）（P = 0.03）。平均粒径（等效圆直径：TDR，0.46μm; THA0.53μm，P = 0.60）和平均形状在TDR和THA之间相当（长宽比：TDR，1.89; THA，1.99，P = 0.35;圆度：TDR ，0.58; THA，0.56，P = 0.35）。然而，TDR颗粒倾向于更小和更圆。尽管在UHMWPE芯的可见损伤与UHMWPE颗粒的浓度或形状之间未发现相关性，但在TDR芯的粒径增加和边缘渗透增加之间发现正相关（P = 0.04）。尽管浓度较低，但TDR组织中存在相似大小和形状的UHMWPE颗粒，这可能解释了为什么与THA不同，疼痛而不是溶骨是修复手术的主要原因。

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