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首页> 外文期刊>Acta biomaterialia >Study of a novel ultrasonically triggered drug vehicle with magnetic resonance properties.
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Study of a novel ultrasonically triggered drug vehicle with magnetic resonance properties.

机译：具有磁共振特性的新型超声触发药物载体的研究。

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摘要

We developed a novel ultrasonically triggered drug vehicle with magnetic resonance (MR) properties by encapsulating superparamagnetic iron oxide (SPIO) nanoparticles in hydroxyapatite (HA)-coated liposomes. The effects of HA coating on the background leakage, ultrasound response and MR signal were investigated. HA coating of liposomes significantly reduced the background leakage of liposome. It also enhanced their sensitivity to ultrasound regardless of HA thickness or ultrasound frequency, even under sonication conditions of high frequency (1 and 3 MHz) and low power density (0.2-0.4 Wcm(-2)) used for diagnosis. However, it was found that the ultrasonically triggered vehicle could exhibit T(2) contrast in MR images by encapsulating SPIO. However, HA coating reduced the r(2) value of SPIO encapsulated in liposomes, but had no significant effect on the r(2)( *) value, implying that MR images of HA-coated liposomes encapsulating SPIO could be probed by the T(2)( *) signal. Most importantly, the r(2)( *)-r(2) value of HA-coated liposomes encapsulating SPIO decreased after sonication, suggesting that the proposed vehicle could be used not only as a MR-guided drug vehicle capable of ultrasonically triggered release but also as a MR reporter to probe ultrasonic triggering.
机译：我们通过将超顺磁性氧化铁（SPIO）纳米颗粒包裹在羟基磷灰石（HA）包衣的脂质体内，开发了一种具有磁共振（MR）特性的新型超声触发药物载体。研究了HA涂层对本底泄漏，超声响应和MR信号的影响。脂质体的HA涂层显着减少了脂质体的背景泄漏。无论HA厚度或超声频率如何，即使在用于诊断的高频（1和3 MHz）和低功率密度（0.2-0.4 Wcm（-2））的超声条件下，它也提高了其对超声的敏感性。但是，发现通过封装SPIO，超声触发的车辆可以在MR图像中显示T（2）对比度。但是，HA涂层降低了脂质体中包裹的SPIO的r（2）值，但对r（2）（*）值没有显着影响，这意味着T可以探测T包裹HA包裹的脂质体的MR图像。 （2）（*）信号。最重要的是，超声处理后，包裹SPIO的HA包被脂质体的r（2）（*）-r（2）值降低，这表明所提出的载体不仅可以用作能够超声触发释放的MR引导药物载体而且还可以作为MR报告器来探测超声触发。

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