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首页> 外文期刊>Acta biomaterialia >Through-thickness control of polymer bioresorption via electron beam irradiation.
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Through-thickness control of polymer bioresorption via electron beam irradiation.

机译：通过电子束辐照控制聚合物生物吸收的全层厚度。

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摘要

Predicable and controlled degradation is not only central to the accurate delivery of bioactive agents and drugs, it also plays a vital role in key aspects of bone tissue engineering. The work addressed in this paper investigates the utilisation of e-beam irradiation in order to achieve a controlled (surface) degradation profile. This study focuses on the modification of commercially and clinically relevant materials, namely poly(L-lactic acid) (PLLA), poly(L-lactide-hydroxyapatite) (PLLA-HA), poly(L-lactide-glycolide) co-polymer (PLG) and poly(L-lactide-DL-lactide) co-polymer (PLDL). Samples were subjected to irradiation treatments using a 0.5MeV electron beam with delivered surface doses of 150 and 500 kGy. In addition, an acrylic attenuation shield was used for selected samples to control the penetration of the e-beam. E-beam irradiation induced chain scission in all polymers, as characterized by reduced molecular weights and glass transition temperatures (T(g)). Irradiation not only produced changes in the physical properties of the polymers but also had associated effects on surface erosion of the materials during hydrolytic degradation. Moreover, the extent to which both mechanical and hydrolytic degradation was observed is synonymous with the estimated penetration of the beam (as controlled by the employment of an attenuation shield).
机译：可预测和受控的降解不仅是生物活性剂和药物准确递送的核心，而且在骨组织工程的关键方面也起着至关重要的作用。本文研究的工作调查了电子束辐照的利用，以实现可控的（表面）降解曲线。这项研究的重点是对商业和临床相关材料的改性，即聚（L-乳酸）（PLLA），聚（L-丙交酯-羟基磷灰石）（PLLA-HA），聚（L-丙交酯-乙交酯）共聚物（PLG）和聚（L-丙交酯-DL-丙交酯）共聚物（PLDL）。使用0.5MeV电子束以150和500kGy的递送表面剂量对样品进行辐照处理。另外，丙烯酸衰减屏蔽被用于选择的样品以控制电子束的穿透。电子束辐照引起所有聚合物的断链，其特征是分子量降低和玻璃化转变温度（T（g））降低。辐照不仅会改变聚合物的物理性能，而且还会在水解降解过程中对材料的表面侵蚀产生相关影响。此外，观察到的机械降解和水解降解的程度与估计的光束穿透度是同义的（受衰减屏蔽的控制）。

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