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首页> 外文期刊>Acta biomaterialia >In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres.
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In vitro degradation rate of apatitic calcium phosphate cement with incorporated PLGA microspheres.

机译：掺入PLGA微球的磷灰石磷酸钙水泥的体外降解率。

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摘要

Calcium phosphate cements (CPCs) are frequently used as bone substitute material. Despite their superior clinical handling and excellent biocompatibility, they exhibit poor degradability, which limits bone ingrowth into the implant. Microspheres were prepared from poly(d,l-lactic-co-glycolic acid) (PLGA) and included in injectable CPCs as porogens in order to enhance its macroporosity after the polymeric microspheres had degraded. Upon degradation of the PLGA microspheres, acid is produced that enhances the dissolution rate of the CPC. However, the effect of the characteristics of PLGA microspheres on the degradation rate of CPCs has never been studied before. Therefore, the purpose of the current study was to investigate the dependence of CPC degradation on the chemical and morphological characteristics of incorporated PLGA microspheres. With respect to the chemical characteristics of the PLGA microspheres, the effects of both PLGA molecular weight (5, 17 and 44kDa) and end-group functionalization (acid-terminated or end-capped) were studied. In addition, two types of PLGA microspheres, differing in morphology (hollow vs. dense), were tested. The results revealed that, although both chemical parameters clearly affected the polymer degradation rate when embedded as hollow microspheres in CPC, the PLGA and CPC degradation rates were mainly dependent on the end-group functionalization. Moreover, it was concluded that dense microspheres were more efficient porogens than hollow ones by increasing the CPC macroporosity during in vitro incubation. By combining all test parameters, it was concluded that dense PLGA microspheres consisting of acid-terminated PLGA of 17kDa exhibited the highest and fastest acid-producing capacity and correspondingly the highest and fastest amount of porosity. In conclusion, the data presented here indicate that the combination of dense, acid-terminated PLGA microspheres with CPC emerges as a successful combination to achieve enhanced apatitic CPC degradation.
机译：磷酸钙水泥（CPC）通常用作骨替代材料。尽管它们具有出色的临床处理能力和出色的生物相容性，但它们的降解性很差，从而限制了骨骼向内生长到植入物中。微球是由聚（d，l-乳酸-乙醇酸共聚物）（PLGA）制备的，并作为致孔剂包含在可注射的CPC中，以便在聚合物微球降解后增强其大孔性。 PLGA微球降解后，会产生酸，从而提高CPC的溶解速度。但是，以前从未研究过PLGA微球特性对CPC降解速率的影响。因此，本研究的目的是研究CPC降解对掺入的PLGA微球的化学和形态特征的依赖性。关于PLGA微球的化学特性，研究了PLGA分子量（5、17和44kDa）和端基官能化（酸封端或封端）的影响。此外，测试了两种PLGA微球，它们的形态不同（中空与致密）。结果表明，尽管当以空心微球形式嵌入CPC时，两个化学参数都明显影响聚合物的降解速率，但PLGA和CPC的降解速率主要取决于端基官能化。此外，通过在体外温育过程中增加CPC的大孔隙度，可以得出结论，致密的微球比空心的更有效。通过综合所有测试参数，可以得出结论，由17kDa酸封端PLGA组成的致密PLGA微球具有最高和最快的产酸能力，并具有最高和最快的孔隙率。总之，此处提供的数据表明，稠密的，酸封端的PLGA微球与CPC的结合是成功实现磷化CPC降解的成功结合。

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