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首页> 外文期刊>Acta biomaterialia >Biomaterial implants mediate autologous stem cell recruitment in mice.
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Biomaterial implants mediate autologous stem cell recruitment in mice.

机译：生物材料植入物在小鼠中介导自体干细胞募集。

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Autologous stem cells, recognized as the best cells for stem cell therapy, are associated with difficult extraction procedures which often lead to more traumas for the patients and time-consuming laboratory work, which delays their subsequent application. To combat such challenges, it was recently uncovered that, shortly after biomaterial implantation, following the recruitment of inflammatory cells, substantial numbers of mesenchymal stem cells (MSC) and hematopoietic stem cells (HSC) were recruited to the implantation sites. These multipotent MSC could be differentiated into various lineages in vitro. Inflammatory signals may be responsible for the gathering of stem cells, since there is a good relationship between biomaterial-mediated inflammatory responses and stem cell accumulation in vivo. In addition, the treatment with the anti-inflammatory drug dexamethasone substantially reduced the recruitment of both MSC and HSC. The results from this work support that such strategies could be further developed towards localized recruitment and differentiation of progenitor cells. This may permit the future development of autologous stem cell therapies without the need for tedious cell isolation, culture and transplantation.
机译：自体干细胞被公认为是干细胞治疗的最佳细胞，其提取过程困难，常常给患者带来更多的创伤，并且耗时的实验室工作也延迟了其后续应用。为了应对这些挑战，最近发现，在生物材料植入后不久，在募集炎症细胞之后，大量骨髓间充质干细胞（MSC）和造血干细胞（HSC）被募集到植入部位。这些多能的MSC可以在体外分化为各种谱系。炎症信号可能是干细胞聚集的原因，因为生物材料介导的炎症反应与体内干细胞积累之间存在良好的关系。另外，用抗炎药地塞米松治疗显着减少了MSC和HSC的募集。这项工作的结果表明，可以进一步发展这种策略，以实现祖细胞的局部募集和分化。这可能允许自体干细胞疗法的未来发展，而无需繁琐的细胞分离，培养和移植。

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