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首页> 外文期刊>Acta biomaterialia >Bone-implant interface strength and osseointegration: Biodegradable magnesium alloy versus standard titanium control.
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Bone-implant interface strength and osseointegration: Biodegradable magnesium alloy versus standard titanium control.

机译：骨-植入物界面强度和骨整合：可生物降解的镁合金与标准钛合金对照。

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Previous research on the feasibility of using biodegradable magnesium alloys for bone implant applications mainly focused on biocompatibility and corrosion resistance. However, successful clinical employment of endosseous implants is largely dependent on biological fixation and anchorage in host bone to withstand functional loading. In the present study, we therefore aimed to investigate whether bone-implant interface strength and osseointegration of a novel biodegradable magnesium alloy (Mg-Y-Nd-HRE, based on WE43) is comparable to that of a titanium control (Ti-6Al-7Nb) currently in clinical use. Biomechanical push-out testing, microfocus computed tomography and scanning electron microscopy were performed in 72 Sprague-Dawley rats 4, 12 and 24 weeks after implantation to address this question. Additionally, blood smears were obtained from each rat at sacrifice to detect potential systemic inflammatory reactions. Push-out testing revealed highly significantly greater maximum push-out force, ultimate shear strength and energy absorption to failure in magnesium alloy rods than in titanium controls after each implantation period. Microfocus computed tomography showed significantly higher bone-implant contact and bone volume per tissue volume in magnesium alloy implants as well. Direct bone-implant contact was verified by histological examination. In addition, no systemic inflammatory reactions were observed in any of the animals. We conclude that the tested biodegradable implant is superior to the titanium control with respect to both bone-implant interface strength and osseointegration. These results suggest that the investigated biodegradable magnesium alloy not only achieves enhanced bone response but also excellent interfacial strength and thus fulfils two critical requirements for bone implant applications.
机译：先前关于将生物可降解镁合金用于骨植入物的可行性的研究主要集中在生物相容性和耐腐蚀性上。然而，骨内植入物的成功临床应用在很大程度上取决于生物固定和锚固在宿主骨中以承受功能负荷。因此，在本研究中，我们旨在研究新型可生物降解镁合金（基于WE43的Mg-Y-Nd-HRE）的骨-植入界面强度和骨整合度是否与钛对照（Ti-6Al- 7Nb）目前在临床上使用。植入后第4、12和24周，对72只Sprague-Dawley大鼠进行了生物力学推出测试，微焦点计算机断层扫描和扫描电子显微镜，以解决这个问题。另外，处死时从每只大鼠获得血液涂片以检测潜在的全身性炎症反应。推出试验显示，在每个植入期后，镁合金棒的最大推出力，极限剪切强度和破坏吸收能量要比钛对照组高得多。 Microfocus计算机断层扫描显示镁合金植入物中的骨-植入物接触和单位组织体积的骨量也明显更高。通过组织学检查证实直接的骨-植入物接触。另外，在任何动物中均未观察到全身性炎症反应。我们得出的结论是，就骨-植入物界面强度和骨整合而言，经过测试的可生物降解植入物优于钛对照。这些结果表明，所研究的可生物降解镁合金不仅实现了增强的骨骼反应，而且还具有出色的界面强度，因此满足了骨植入应用的两个关键要求。

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