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首页> 外文期刊>Acta biomaterialia >A poly(l-lysine)-based hydrophilic star block co-polymer as a protein nanocarrier with facile encapsulation and pH-responsive release
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A poly(l-lysine)-based hydrophilic star block co-polymer as a protein nanocarrier with facile encapsulation and pH-responsive release

机译：一种基于聚（1-赖氨酸）的亲水性星型嵌段共聚物，作为蛋白质纳米载体，具有易于封装和pH响应释放的特点

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摘要

A hydrophilic star block co-polymer was synthesized, characterized, and evaluated as a protein nanocarrier. The star block co-polymer was composed of a hyperbranched polyethylenimine (PEI) core, a poly(l-lysine) (PLL) inner shell, and a poly(ethylene glycol) (PEG) outer shell. The model protein insulin can be rapidly and efficiently encapsulated by the synthesized polymer in aqueous phosphate buffer at physiological pH. Complexation between PEI-PLL-b-PEG and insulin was investigated using native polyacrylamide gel electrophoresis. The uptake of enhanced green fluorescent protein into Ad293 cells mediated by PEI-PLL-b-PEG was also investigated. The encapsulated insulin demonstrated sustained release at physiological pH and showed accelerated release when the pH was decreased. The insulin released from the star block co-polymer retained its chemical integrity and immunogenicity.
机译：合成，表征和评估亲水性星形嵌段共聚物作为蛋白质纳米载体。星形嵌段共聚物由超支化聚乙烯亚胺（PEI）核，聚（1-赖氨酸）（PLL）内壳和聚（乙二醇）（PEG）外壳组成。模型蛋白胰岛素可以被合成的聚合物快速有效地封装在生理pH的磷酸盐水溶液中。使用天然聚丙烯酰胺凝胶电泳研究了PEI-PLL-b-PEG与胰岛素之间的络合。还研究了PEI-PLL-b-PEG介导的增强型绿色荧光蛋白对Ad293细胞的摄取。包封的胰岛素在生理pH下显示出持续释放，并在pH降低时显示出加速释放。从星形嵌段共聚物释放的胰岛素保留了其化学完整性和免疫原性。

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