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首页> 外文期刊>Acta biomaterialia >Design and characterization of sulfobetaine-containing terpolymer biomaterials
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Design and characterization of sulfobetaine-containing terpolymer biomaterials

机译：含磺基甜菜碱的三元共聚物生物材料的设计与表征

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A methacrylic terpolymer system with non-fouling interfacial properties was synthesized by the random copolymerization of hexyl methacrylate, methyl methacrylate and sulfobetaine methacrylate (a monomer bearing a zwitterionic pendant group). Polymers were synthesized from feeds containing 0-15 mol.% of the zwitterion-containing methacrylate. Proton nuclear magnetic resonance verified the incorporation of sulfobetaine methacrylate into the polymer structure. Water absorption studies illustrate that the hydrophilicity of the material increases with increasing zwitterion concentration. The biological properties of the polymer were probed by fibrinogen adsorption, human umbilical vein endothelial cell adhesion and growth, and platelet adhesion. Strong resistance to protein adsorption and cell and platelet attachment was observed on materials synthesized from 15 mol.% sulfobetaine methacrylate. Results were compared to the non-fouling behavior of a PEGylated terpolymer formulation and it was observed that the poly(ethylene glycol)-containing materials were slightly more effective at resisting human umbilical vein endothelial cell adhesion and growth over a 7 day incubation period, but the zwitterion- containing materials were equally effective at resisting fibrinogen adsorption and platelet adhesion. The zwitterion-containing materials were electrospun into three-dimensional random fiber scaffolds. Materials synthesized from 15 mol.% of the zwitterion-containing monomer retained their non-fouling character after fabrication into scaffolds.
机译：通过无规共聚甲基丙烯酸己酯，甲基丙烯酸甲酯和磺基甜菜碱甲基丙烯酸酯（带有两性离子侧基的单体），合成了具有防污界面特性的甲基丙烯酸三元共聚物体系。由含有0-15mol。％的含两性离子的甲基丙烯酸酯的进料合成聚合物。质子核磁共振证实了甲基丙烯酸磺基甜菜碱掺入聚合物结构。吸水率研究表明，该材料的亲水性随两性离子浓度的增加而增加。通过纤维蛋白原吸附，人脐静脉内皮细胞粘附和生长以及血小板粘附来探测聚合物的生物学特性。在由15 mol％的甲基丙烯酸磺基甜菜碱合成的材料上，观察到了对蛋白质吸附以及细胞和血小板附着的强抵抗力。将结果与PEG化三元共聚物配方的无污垢行为进行了比较，结果发现，含聚乙二醇的材料在7天的温育期中对人脐静脉内皮细胞粘附和生长的抵抗力稍强，但含两性离子的材料在抵抗纤维蛋白原吸收和血小板粘附方面同样有效。将含两性离子的材料电纺成三维无规纤维支架。由15摩尔％的两性离子单体合成的材料在制成支架后仍保持其防污特性。

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