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首页> 外文期刊>Acta biomaterialia >Salicylic acid-releasing polyurethane acrylate polymers as anti-biofilm urological catheter coatings
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Salicylic acid-releasing polyurethane acrylate polymers as anti-biofilm urological catheter coatings

机译：水杨酸释放聚氨酯丙烯酸酯聚合物作为抗生物膜泌尿科导管涂层

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摘要

Biofilm-associated infections are a major complication of implanted and indwelling medical devices like urological and venous catheters. They commonly persist even in the presence of an oral or intravenous antibiotic regimen, often resulting in chronic illness. We have developed a new approach to inhibiting biofilm growth on synthetic materials through controlled release of salicylic acid from a polymeric coating. Herein we report the synthesis and testing of a ultraviolet-cured polyurethane acrylate polymer composed, in part, of salicyl acrylate, which hydrolyzes upon exposure to aqueous conditions, releasing salicylic acid while leaving the polymer backbone intact. The salicylic acid release rate was tuned by adjusting the polymer composition. Anti-biofilm performance of the coatings was assessed under several biofilm forming conditions using a novel combination of the MBEC Assay? biofilm multi-peg growth system and bioluminescence monitoring for live cell quantification. Films of the salicylic acid-releasing polymers were found to inhibit biofilm formation, as shown by bioluminescent and GFP reporter strains of Pseudomonas aeruginosa and Escherichia coli. Urinary catheters coated on their inner lumens with the salicylic acid-releasing polymer significantly reduced biofilm formation by E. coli for up to 5 days under conditions that simulated physiological urine flow.
机译：与生物膜有关的感染是植入式和留置式医疗设备（如泌尿外科和静脉导管）的主要并发症。即使在口服或静脉内抗生素治疗的情况下，它们通常也会持续存在，经常导致慢性疾病。我们已经开发出一种新方法，可通过控制聚合物涂料中水杨酸的释放来抑制合成材料上生物膜的生长。本文中，我们报告了部分由丙烯酸水杨酯组成的紫外线固化聚氨酯丙烯酸酯聚合物的合成和测试，该聚合物在暴露于水性条件下会水解，释放出水杨酸，同时保持聚合物骨架完整。通过调节聚合物组成来调节水杨酸的释放速率。使用MBEC Assay？的新型组合在几种生物膜形成条件下评估了涂料的抗生物膜性能。生物膜多钉生长系统和生物发光监测，用于活细胞定量。如铜绿假单胞菌和大肠杆菌的生物发光和GFP报告菌株所示，发现水杨酸释放聚合物的膜抑制生物膜的形成。在模拟生理尿流的条件下，用水杨酸释放聚合物覆盖其内腔的导尿管可最多减少5天的大肠杆菌生物膜形成。

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