• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Structural, morphological and surface characteristics of two types of octacalcium phosphate-derived fluoride-containing apatitic calcium phosphates
【24h】

Structural, morphological and surface characteristics of two types of octacalcium phosphate-derived fluoride-containing apatitic calcium phosphates

机译：两种源自磷酸八钙的含氟磷灰石磷酸钙的结构，形态和表面特征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Octacalcium phosphate (OCP) has been reported to stimulate bone regeneration during hydrolysis into hydroxyapatite (HA). The present study was designed to characterize structural, morphological and surface properties of fluoride-containing apatitic calcium phosphates (CaP) obtained through OCP hydrolysis or direct precipitation of OCP in the presence of 12-230 ppm of fluoride (F). The products were characterized by chemical analysis, X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), selected area electron diffraction (SAED) and Fourier transform infrared spectroscopy (FTIR) as well as measurements of surface area, solubility, osteoblastic activities and bovine serum albumin (BSA) adsorption. XRD analysis re-confirmed that both preparations yielded more apatitic CaP with a higher concentration of F. However, the co-precipitated products (CF-CaP) maintained the properties of OCP, in particular the solubility, whereas the hydrolysis products (HF-CaP) had the characteristics of fluoridated apatite. The crystals of plate-like OCP were changed to the crystals of rod-like CF-CaP and small irregular HF-CaP with the advance of the hydrolysis. The SAED analysis detected both OCP and apatite crystals even in the most hydrolyzed CF-CaP. Mouse bone marrow stromal ST-2 cells grew better on CF-CaP compared with HF-CaP. BSA adsorption was inhibited on HF-CaP more than on CF-CaP. These results show that OCP produces physicochemically distinct apatitic fluoridated CaP during hydrolysis, regarding the structure, the crystal morphology and the protein adsorption, depending on the fluoride introduction route, which provides biologically interesting material.
机译：据报道，磷酸八钙（OCP）可以在水解成羟磷灰石（HA）的过程中刺激骨骼再生。本研究旨在表征通过OCP水解或在12-230 ppm的氟化物（F）存在下直接沉淀OCP而获得的含氟化物的磷酸钙磷酸钙（CaP）的结构，形态和表面特性。产品通过化学分析，X射线衍射（XRD），场发射扫描电子显微镜（FE-SEM），透射电子显微镜（TEM），选择区域电子衍射（SAED）和傅里叶变换红外光谱（FTIR）进行表征。以及表面积，溶解度，成骨活性和牛血清白蛋白（BSA）吸附的测量。 XRD分析再次证实，两种制剂均能以更高的F浓度生成更多的脂肪族CaP。但是，共沉淀产物（CF-CaP）保持了OCP的特性，特别是溶解度，而水解产物（HF-CaP） ）具有氟化磷灰石的特性。随着水解的进行，板状OCP的晶体变为棒状CF-CaP和小的不规则HF-CaP的晶体。 SAED分析甚至在水解程度最高的CF-CaP中也检测到了OCP和磷灰石晶体。与HF-CaP相比，CF-CaP小鼠骨髓基质ST-2细胞生长更好。 BSA吸附对HF-CaP的抑制比对CF-CaP的抑制更大。这些结果表明，在结构，晶体形态和蛋白质吸附方面，OCP在水解过程中会产生物理化学上不同的脂族氟化CaP，具体取决于氟化物的引入途径，从而提供了生物学上有意义的材料。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号