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首页> 外文期刊>Acta biomaterialia >Osteostatin-loaded onto mesoporous ceramics improves the early phase of bone regeneration in a rabbit osteopenia model
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Osteostatin-loaded onto mesoporous ceramics improves the early phase of bone regeneration in a rabbit osteopenia model

机译：骨抑制素加载到介孔陶瓷上可改善兔骨质减少模型中骨再生的早期阶段

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摘要

Parathyroid hormone-related protein (PTHrP) is an important modulator of bone formation. Recently, we reported that PTHrP (107-111) (osteostatin) coating onto mesoporous ceramics confers osteogenic activity to these materials. Bone repair is dramatically compromised in osteopenia/osteoporosis. Thus, we examined the efficacy of unmodified and organically modified SBA15 ceramics loaded with osteostatin in promoting bone repair in an osteoporotic rabbit model. Osteoporosis was induced in New Zealand rabbits by methylprednisolone administration, and healthy rabbits were used as controls. Tested materials were implanted into a femoral cavitary defect, and animals were sacrificed at 2 weeks post-implantation. At this time, implants were encapsulated by a variable layer of fibrotic tissue with no evidence of inflammation. Similarly to observations in normal rabbits, both types of osteostatin-loaded bioceramics induced tissue regeneration associated with increased staining for PCNA, Runx2, osteopontin, and/or vascular endothelial growth factor in osteoporotic rabbits. Our present findings demonstrate that these osteostatin-bearing bioceramics increase the early repair response not only in normal bone but also in osteoporotic bone after a local injury.
机译：甲状旁腺激素相关蛋白（PTHrP）是骨形成的重要调节剂。最近，我们报道了在中孔陶瓷上涂覆PTHrP（107-111）（骨抑制素）可赋予这些材料成骨活性。骨质疏松症/骨质疏松症严重损害了骨修复。因此，我们检查了骨质疏松兔模型中未改性和有机改性的载有骨抑素的SBA15陶瓷在促进骨修复中的功效。通过给予甲基强的松龙在新西兰兔中诱发骨质疏松症，并将健康的兔用作对照。将经测试的材料植入股骨腔缺损中，并在植入后2周处死动物。此时，植入物被一层可变的纤维化组织包裹，没有炎症迹象。与正常兔子中的观察结果相似，两种类型的载有骨抑素的生物陶瓷均能诱导组织再生，从而使骨质疏松兔的PCNA，Runx2，骨桥蛋白和/或血管内皮生长因子染色增加。我们目前的发现表明，这些带有骨抑素的生物陶瓷不仅在正常骨骼中而且在局部损伤后的骨质疏松性骨骼中都增加了早期修复反应。

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